Results 1 to 10 of about 35,696 (248)
Ellagic acid attenuates liver toxicity induced by valproic acid in rats
Journal of Pharmacological Sciences, 2020 Valproic acid is a commonly used drug for many psychiatric disorders, particularly for epilepsy. However, it has been reported that its use is associated with possible side effects including hepatotoxicity.The present study investigated the ...
Noha Abdelkader +2 more
exaly +3 more sources
Retrospective Analysis of 2 992 Times of Therapeutic Drug Monitoring of Valproic Acid from 2019 to 2021 [PDF]
Zhongguo quanke yixue, 2023 Background Valproic acid, as a mood stabilizer, has been extensively used for the treatment of bipolar disorder and other psychiatric conditions. Although therapeutic drug monitoring (TDM) of valproic acid has been carried out at home and abroad for many
DING Jing, MENG Zhuocheng, ZHANG Yan, CUI Xiaohua, LIU Jiarui, HE Jiao, ZHANG Yang, LI Yajuan, YANG Liu
doaj +1 more source
Genetic Polymorphisms Associated with Valproic Acid Therapy: Review article
SVU - International Journal of Medical Sciences, 2022 Background: Valproic acid is an important anticonvulsant and mood-stabilizing drug. It is also used in the therapy of bipolar disorders, migraine, cancer and neurodegenerative disorders.
Reham A.M. Ellisy* +4 more
doaj +1 more source
Use of valproic acid in long stay units of psychiatry [PDF]
Farmacia Hospitalaria, 2015 Objective: Valproic acid is often used in psychiatry to treat schizophrenia and other conditions outside of indication (“off-label”). However, its effectiveness has not been sufficiently demonstrated and its use is not exempt of adverse effects.
Mª Teresa Martínez-Lazcano +5 more
doaj +1 more source
Scientific Reports, 2021 Valproic acid is an anticonvulsant, which is also widely used for treating psychiatric disorders. Some clinical trials have demonstrated benefits of valproic acid augmentation therapy in schizophrenia.
S. Wang +7 more
doaj +1 more source
Pharmaceuticals, 2023 Genetic polymorphisms in ATP-binding cassette subfamily B member 1 (ABCB1, also known as MDR1) have been reported to be possibly associated with the regulation of response to antiseizure medications.
Jiahao Zhu +7 more
doaj +1 more source
Pharmacological modulation of cell functional activity with valproic acid and erythropoietin [PDF]
Research Results in Pharmacology, 2019 Introduction: Valproic acid (VA) is carboxylic acid with a branched chain, which is used as an antiepileptic drug. Valproic acid influence on cells in vivo: VA, which is an antiepileptic drug, is also a teratogen, which causes defects ...
Polina A. Golubinskaya +8 more
doaj +3 more sources
Valproic acid-induced hyperammonemic encephalopathy: a clinical case
European Psychiatry, 2022 Introduction Valproic acid is a psychotropic drug used for several years, due to its properties as a mood stabilizer, being considered as first-line treatment for bipolar disorder.
M. Felizardo, C. Freitas
doaj +1 more source
Antioxidative effect of metformin on valproic acid induced hepatoxicity in male rats
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Metformin is 1,1-dimethylbiguanide hydrochloride, is the first-line therapy for type 2 diabetes. Additionally, several studies focused on the role of metformin in antioxidant activities for the treatment of hepatic disorders. The experimentally
Intesar Tarik Numan +2 more
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Serum concentrations of valproic acid in people with epilepsy: Clinical implication [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Therapeutic drug monitoring (TDM) allows personalizing the dose of valproic acid in patients with epilepsy to optimize drug therapy, minimize adverse effects and detect interactions.
Angel T. Alvarado +12 more
doaj +1 more source