Results 21 to 30 of about 35,696 (248)

Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested.
Mohammad Shokrzadeh, Abbas Mohammad pour, Zahra Tajik, Maryam Alizadeh, Shaghayegh Aghajanshakeri   +4 more
doaj  

Marjoram Oil Attenuates Valproic Acid-Induced Pancreatic Damage in Adult Male Albino Rats: A Histological and Immunohistochemical Study [PDF]

The Egyptian Journal of Histology, 2022
Introduction: Valproic acid [VA] is an antiepileptic drug that is extensively prescribed for many neurological disorders. Its use is associated with serious pancreatic complications. Marjoram oil [MO] is a health protective agent with proved anti-oxidant
Amira Kassab, Heba Sharaf Eldin, Amal Abd-El-Hafez   +2 more
doaj   +1 more source

Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction

Case Reports in Psychiatry, 2014
Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event.
Jennifer D. Twilla, Andrew S. Pierce
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Impact of enriched environment on retinal thickness in zebrafish exposed to valproic acid [PDF]

Revista Brasileira de Oftalmologia
Objective: Embryonic exposure to valproic acid is a widely used model for the study of neurodevelopmental disorders such as autism spectrum disorders.
Mariana Aguirre-Rebolledo, Maria Rebeca Toledo-Cardenas, Elizabeth Valero-Pacheco, Ana María Aguirre-Martínez, Bernardo Flores-Prieto   +4 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic –Clonic Seizures in Adults – A Randomized Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Idiopathic Generalized Tonic-Clonic Seizures (GTCS) are frequently encountered in adults. Their successful control is necessary to improve the quality of life of these patients.
VISHAL PRAKASH GIRI, OM PRAKASH GIRI, FARHAN AHMAD KHAN, NARENDRA KUMAR, AJAY KUMAR, ATAUL HAQUE   +5 more
doaj   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Evaluation of Antitumor Activity of Valproic Acid on K562 cells: In Vitro [PDF]

Journal of Fasa University of Medical Sciences, 2016
Backgrond & Objective: This study was performed to evaluate the antitumor effects of valproic acid (VPA) drug on K562 cells in vitro. Material & Methods: For this purpose, K562 cells were cultured and treated with different doses of valproic acid, and ...
Shahin Aalaei Diman, Mehdi Mohamadzade, Yaghub Pazhang   +2 more
doaj   +1 more source