Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo [PDF]
, 2013 Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents.
Eva Juengel +13 more
core +2 more sources
Electrochemical Degradation and Thermal Deactivation of Valproic Acid Drug
International Journal of Electrochemical Science, 2021 Electrochemical degradation of valproic acid drug (VAc) was studied by direct and indirect electrochemical oxidation processes using platinum electrode.
Simona Iordache +5 more
doaj +1 more source
The anti-epileptic drug Valproic Acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro [PDF]
, 2012 Valproic acid (VPA) is used widely to treat epilepsy and bipolar disorder. Women undergoing VPA treatment reportedly have an increased incidence of polycystic ovarian syndrome (PCOS)-like symptoms including hyperandrogenism and oligo- or amenorrhoea.
Knight, PG +19 more
core +2 more sources
Valproic Acid-Associated Acute Pancreatitis: Systematic Literature Review. [PDF]
, 2023 Long-term medication with valproic acid has been associated with acute pancreatitis. The purpose of this report is to gain insight into the features of this pancreatitis.
Stadelmann, MIE +7 more
core +3 more sources
Clinical and Translational Science, 2023 Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods.
Toshihiko Yoshioka +13 more
doaj +1 more source
Maternal Swimming Exercise During Pregnancy Improves Memory Through Enhancing Neurogenesis and Suppressing Apoptosis via Wnt/β-Catenin Pathway in Autistic Mice [PDF]
International Neurourology Journal, 2021 Purpose Wnt pathway is closely related to neurodevelopmental process associated with cognitive function. After administration of valproic acid to the pregnant mice, the effect of swimming exercise of pregnant mice on the memory, neuronal production, and ...
Sang-Seo Park +4 more
doaj +1 more source
Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients. [PDF]
Clin Pharmacol TherPersonalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Jang YJ, Heo DG, Hong E.
europepmc +2 more sources
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction
Prague Medical Report, 2017 We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration ...
Martin Šíma +4 more
doaj +1 more source
Antidepressant effects of valproic acid in an animal model of depression
European Pharmaceutical Journal, 2019 Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of valproic acid has not been sufficiently characterized so far. The aim of the present study was
Buzgoova K. +3 more
doaj +1 more source
Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested.
Mohammad Shokrzadeh +4 more
doaj