Results 31 to 40 of about 2,544,276 (249)
Frontiers in Cell and Developmental Biology, 2022 Neuroinflammation is a critical and targetable pathogenic component of neurodegenerative diseases, including glaucoma, the leading cause of irreversible blindness.
James R. Tribble +5 more
doaj +1 more source
Klinik Psikiyatri DergisiValproic acid is a mood stabilizer and antiepileptic drug that acts through GABA and glutamate. Glutamatergic and GABAergic dysfunction is thought to be a common mechanism in the pathophysiology of autism spectrum disorder and obsessive-compulsive ...
Elif Betül Aydoğan +2 more
doaj +1 more source
, 2017 The effects of the phosphorylation state of the glycogen synthase kinase 3 beta involved in the cardiac myocytes (jelly-like cells) epithelial-mesenchymal transition-associated migration during heart-valve formation were examined through the valproic ...
游偉絢;劉宏輝;何奕倫 +1 more
core +1 more source
, 2021 (A-B) Tolerance to morphine was developed by repeated injections, while pretreatment with valproic acid one hour before each morphine injection inhibited the expression of tolerance to morphine.
Yaghoub Fathollahi (778334) +4 more
core +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Determination of free and total valproic acid in human plasma by capillary electrophoresis with contactless conductivity detection [PDF]
, 2012 A new approach for the determination of free and total valproic acid in small samples of 140 µL human plasma based on capillary electrophoresis with contactless conductivity detection is proposed.
Morand, Réjane +12 more
core +1 more source
Impact of enriched environment on retinal thickness in zebrafish exposed to valproic acid [PDF]
Revista Brasileira de OftalmologiaObjective: Embryonic exposure to valproic acid is a widely used model for the study of neurodevelopmental disorders such as autism spectrum disorders.
Mariana Aguirre-Rebolledo +4 more
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
VALPROIC ACID: AN OLD DRUG WITH NEW INDICATION
, 2023 Valproic acid (VPA) is frequently featured in the treatment of bipolar disorder and epilepsy and has entered the clinical field for decades with established pharmacokinetics and a safe side effects profile.
Sun, Zhaoran
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source