Results 51 to 60 of about 35,696 (248)

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Nomogram for the prediction of valproic acid induced platelet decline: a nested case–control study

Scientific Reports
Platelet decline is a frequent side effect of valproic acid, a medication commonly prescribed to prevent seizures in neurosurgical patients. However, the risk factors for valproic acid-associated platelet decline remain poorly understood, and it remains ...
Gang Cheng, Xinfeng Cai, Tianning Zhang, Jinlin Guo, Jiuhong Ma, Xiufeng Zhang, Xingang Li   +6 more
doaj   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, EarlyView.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

Epilepsy characteristics in patients with muscle‐eye‐brain disease: A systematic review of electroclinical features

Epileptic Disorders, EarlyView.
Abstract Background and Objectives Muscle‐Eye‐Brain disease (MEB) is a dystroglycanopathy that belongs to the congenital muscular dystrophies. Central nervous system manifestations include congenital brain abnormalities, neurodevelopmental delay, and epilepsy, making it a rare but important cause of developmental and epileptic encephalopathy.
Stefania Kalampokini, Evripidis Pityrigkas, Eleni Liouta, Georgia Pepe, Vasiliki Poulidou, Martha Spilioti, Vasilios K. Kimiskidis   +6 more
wiley   +1 more source

Reversible central respiratory events induced by valproic acid treatment: A case report

SAGE Open Medical Case Reports
Valproic acid holds a prominent position as the primary therapeutic option for epilepsy cases. The utilization of antiepileptic agents like valproic acid has been linked to disturbances in sleep architecture.
Chirine Moussa, Nour Mahmoud, Houda Rouis, Amel Khattab, Ibtihel Khouaja, Leila Bayahi, Ines Zendah, Sonia Maâlej   +7 more
doaj   +1 more source

Anti-angiogenic effects of valproic acid in a mouse model of oxygen-induced retinopathy

Journal of Pharmacological Sciences, 2018
Pathological retinal angiogenesis contributes to the pathogenesis of several ocular diseases. Valproic acid, a widely used antiepileptic drug, exerts anti-angiogenic effects by inhibiting histone deacetylase (HDAC). Herein, we investigated the effects of
Naoto Iizuka, Akane Morita, Chihiro Kawano, Asami Mori, Kenji Sakamoto, Masakazu Kuroyama, Kunio Ishii, Tsutomu Nakahara   +7 more
doaj   +1 more source

Effect of valproic acid on Expression of Bim gene and viability of ovarian cancer cell line A2780

مجله دانشگاه علوم پزشکی گرگان, 2017
Background and Objective: Ovarian cancer is the fifth common cancer among women and the number of new cases is increasing. Valproic acid is a histone deacetylase inhibitor effectively used to treat epilepsy and bipolar disease.
Z Amini-Farsani, MH Sangtarash, H Teimori, M Shamsara   +3 more
doaj  

Delayed brain and spine migration of a retained SEEG electrode fragment: An unexpected complication

Epileptic Disorders, EarlyView.
Abstract Background Stereoelectroencephalography (SEEG) is a well‐established technique for localizing epileptogenic zones in patients with drug‐resistant epilepsy, including children. While considered safe, rare but serious complications can occur.
Manel Krouma, Julia Makhalova, Gauthier Toutain, Francesca Pizzo, Stanislas Lagarde, Anne Lepine, Fabrice Bartolomei, Didier Scavarda   +7 more
wiley   +1 more source

The second unprovoked seizure in a cohort of treated patients with a first unprovoked seizure

Epileptic Disorders, EarlyView.
Abstract Objectives To evaluate the rate of a second unprovoked seizure in antiseizure medications (ASMs)‐treated patients following a first unprovoked seizure and to identify potential risk factors associated with its occurrence. Methods A retrospective review of the computerized database and the medical records of all the patients who presented to ...
Revital Gandelman‐Marton, Jacques Theitler   +1 more
wiley   +1 more source

Anti-tumor effects of valproic acid and 1, 25 dihydroxy vitamin D3 on HL-60 cancer cells

یافته‌های نوین در علوم زیستی, 2018
11, 25 dihydroxy vitamin D3, an active metabolite of vitamin­D3 has been reported to inhibit the growth of number neoplasms such as prostate, breast, colorectal, leukemia and skin cancers.
Maryam Rihimi
doaj