Results 61 to 70 of about 2,544,276 (249)

Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy

Cells, 2019
Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment.
Ida Sofie Grønningsæter, Hanne Kristin Fredly, Bjørn Tore Gjertsen, Kimberley Joanne Hatfield, Øystein Bruserud   +4 more
doaj   +1 more source

When meta‐analyses mislead: Promises and pitfalls in teratology counselling

British Journal of Clinical Pharmacology, EarlyView.
Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley   +1 more source

Measuring the appropriateness of carbamazepine and valproic acid prescribing and utilization using a newly implemented online system in the Tabuk Region of Saudi Arabia

Saudi Pharmaceutical Journal, 2020
Epilepsy is a common neurologic disorder, which is efficiently treated with carbamazepine and valproic acid. Moreover, Saudi Ministry of Health implemented a new E-system for Poison Control Centers called Awtar to enhance technology utilization in ...
Reem S Al-Balawi, Mohammed A Alshehri, Abdullah S Alatawi, Abdullah M Al Shehri, Manal A Alshehry, Mohammed M.H. Al-Gayyar   +5 more
doaj   +1 more source

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2‐Related Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata, Chhitij Tiwari, Zheng Fan, Muge Gucsavas‐Calikoglu, Yael Shiloh‐Malawsky, Kimberly S. Foss, Stephanie N. Peck, Erin L. Heinzen, Chon Lee, Senyene E. Hunter   +9 more
wiley   +1 more source

"ALTERED PLASMA ZINC LEVEL CONTRIBUTES TO THE DEVELOPMENTAL TOXICITY OF VALPROIC ACID IN SKELETAL SYSTEM OF RAT" [PDF]

Acta Medica Iranica, 2004
Valproic acid is one of the main antiepileptic drugs. There is an increased risk of neural tube defects and axial skeletal malformations among infants born to women who had received valproic acid.
M.Akbari1, F. Abolhassani, M. Azizi, A.R. Dehpour, M.Ansari, M.A. Ahmadi Faghih A. Hedayatpour   +5 more
doaj   +1 more source

Valproic acid induced pancreatitis: a case report [PDF]

, 2017
Valproic acid is a commonly used antiepileptic drug. Apart from its common side effect there is definite association between valproic acid therapy and acute pancreatitis.
Barman, Bhupen, Kalotia, Niraj, Ete, Tony   +2 more
core  

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke, Diego M. Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane A. Sievi, Marco Di Donato, Anton Schmick, Jonas Herth, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +12 more
wiley   +1 more source

Nomogram for the prediction of valproic acid induced platelet decline: a nested case–control study

Scientific Reports
Platelet decline is a frequent side effect of valproic acid, a medication commonly prescribed to prevent seizures in neurosurgical patients. However, the risk factors for valproic acid-associated platelet decline remain poorly understood, and it remains ...
Gang Cheng, Xinfeng Cai, Tianning Zhang, Jinlin Guo, Jiuhong Ma, Xiufeng Zhang, Xingang Li   +6 more
doaj   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Reversible central respiratory events induced by valproic acid treatment: A case report

SAGE Open Medical Case Reports
Valproic acid holds a prominent position as the primary therapeutic option for epilepsy cases. The utilization of antiepileptic agents like valproic acid has been linked to disturbances in sleep architecture.
Chirine Moussa, Nour Mahmoud, Houda Rouis, Amel Khattab, Ibtihel Khouaja, Leila Bayahi, Ines Zendah, Sonia Maâlej   +7 more
doaj   +1 more source