Results 81 to 90 of about 2,544,276 (249)

Valproic acid induces caspase 3-mediated apoptosis in microglial cells

, 2006
Valproic acid is widely used for the treatment of epilepsy and mood disorders, but its mode of action is unclear. Treatment of neuronal cells with valproic acid promotes neurite sprouting, is neuroprotective and drives neurogenesis; however its effects ...
OCarroll, Simon, Cameron, Rachel, Gibbons, Hannah, Narayan, Pritika, Pearson, Andree, Dragunow, Michael, Greenwood, Jeffrey   +6 more
core   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

Effect of valproic acid and radiotherapy on viability of MCF-7 breast cancer cell line

مجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: Valproic acid is used in the epilepsy, bipolar and migraine therapy. As a histone deacetylase inhibitor, Valproic acid has been recently under investigation in cancer treatment, either alone or in combination with either ...
Aghagolzade Haji H, Khoshbin Khoshnazar AR, Gharaei R, Javan B, Asadi J   +4 more
doaj  

Valproate-induced thrombocytopenia

Лечащий Врач
Background. Valproic acid is widely prescribed as an antiepileptic drug and mood stabilizer. Fatigue, tremor, sedation, hepatotoxicity, weight gain, hair loss and thrombocytopenia have been reported as side effects.
N. V. Izmozherova, A. A. Popov, I. P. Antropova, L. I. Kadnikov, D. A. Kruzhevnikova, O. A. Makarova   +5 more
doaj   +1 more source

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy

Epileptic Disorders, EarlyView.
Abstract Background and Objectives KBG syndrome is a rare autosomal developmental disorder caused by pathogenic variants of the ANKRD11 gene. This scoping review aimed to explore all current literature data regarding clinical and electroencephalographic features of patients with KBG syndrome and epilepsy. Materials and Methods We conducted a literature
Stefania Kalampokini, Evripidis Pityrigkas, Zoi Kallia, Georgia Pepe, Antonis Frontistis, Dimitrios Profer, Vasilios Kimiskidis   +6 more
wiley   +1 more source

Simultaneous determination of asenapine and valproic acid in human plasma using LC–MS/MS: Application of the method to support pharmacokinetic study

Journal of Pharmaceutical Analysis, 2013
Combination of asenapine with valproic acid received regulatory approval for acute treatment of schizophrenia and maniac episodes of bipolar disorders.
Ambavaram Vijaya Bhaskar Reddy, Nandigam Venugopal, Gajulapalle Madhavi   +2 more
doaj   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Valproic Acid-Associated Vanishing Bile Duct Syndrome

, 2010
Hepatotoxicity as a result of valproic acid therapy is well documented. Elevation in aminotransferase activities is rarely associated with symptoms. It sometimes manifests as acute liver failure.
Durmaz, Oezlem, Gulluoglu, Mine, Sokucu, Semra, Celtik, Coskun, Gokce, Selim, Aydogan, Aysen   +5 more
core   +1 more source

Postoperative outcomes and predictors of functional sequelae following hemispheric surgery in Rasmussen's encephalitis: A retrospective cohort study from the global pediatric epilepsy surgery registry

Epileptic Disorders, EarlyView.
Abstract Objective Rasmussen's encephalitis (RE) is a rare and progressive, immune‐mediated epileptic encephalopathy characterized by drug‐resistant seizures and neurological decline. While hemispheric disconnection (HD) is the gold standard treatment for effective seizure control, this procedure carries significant risk of permanent neurological ...
Krish Nair, Nicholas Benjamin, Emily Harford, Levi Shelton, Ariel Heller, Katherine Cobb‐Pitstick, Luis Fernandez, Ross Carson, Monika Jones, William Welch, Taylor J. Abel, Ruba Al‐Ramadhani   +11 more
wiley   +1 more source

The Effect of Valproic Acid on Mesenchymal Pluripotent Cell Proliferation and Differentiation in Extracellular Matrices

, 2011
Valproic acid (2- n -propylpentanoic acid, VPA) is a widely used antiepileptic and anticonvulsant drug. Previous studies have reported that VPA effects osteogenesis in vivo and in vitro, yet it remains unclear whether VPA promotes cell differentiation of
Yuji Hatakeyama, Yoshihiko Sawa, Eichi Tsuruga, Kyoko Oka, Tetsuichiro Inai, Junko Hatakeyama, Atsushi Takahashi   +6 more
core   +1 more source