Severe Valproic Acid Intoxication Responding to Hemodialysis
Journal of Pediatric Emergency and Intensive Care Medicine, 2017 Valproic acid is a commonly used antiepileptic drug which causes intoxication easily due to its narrow therapeutic window. Here, we present a child with valproic acid poisoning who responded to hemodialysis.
Ali Ertuğ Arslanköylü +4 more
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Valproic Acid-induced Agranulocytosis [PDF]
International Journal of Gerontology, 2009 Valproic acid is considered to be the most well-tolerated antiepileptic drug. However, few cases of neutropenia or leukopenia caused by valproic acid have been reported. We present a patient who took valproic acid to treat a complication of brain surgery
Hui-Chuan Hsu +3 more
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Valproic acid induced hyperammonaemic encephalopathy: case report
Psychiatry and Behavioral Sciences, 2014 Hyperammonemia is a well-known adverse effect of valproic acid therapy. In the recent years, encephalopathy cases triggered by vaproic acid use-related hyperammonemia have been reported and regular blood ammonium level follow-up is suggested ...
Gul Eryılmaz +4 more
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Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction
Case Reports in Psychiatry, 2014 Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event.
Jennifer D. Twilla, Andrew S. Pierce
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Betaine reduces valproic acid-induced hepatotoxicity [PDF]
Journal of Mazandaran University of Medical SciencesBackground and purpose: Antiepileptic drugs cause a wide range of side effects in patients, including hepatotoxicity particularly associated with valproic acid.
Amin Hasanvand +6 more
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Inositol supplementation in patients taking lithium or valproic acid: strengthening the multidisciplinary approach [PDF]
, 2023 Dear Editor, I’ve read with great interest the review recently published by Kamenov et al1 about the importance of inositol supplementation in recovering side effects induced by mood stabilizers and anticonvulsant drugs.
Francesca Pacitti
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SHORT-CHAIN CARBOXYLIC-ACIDS, A NEW CLASS OF TERATOGENS - STUDIES OF POTENTIAL BIOCHEMICAL-MECHANISMS [PDF]
, 1986 Certain short-chain carboxylic acids (SCCA) appear to share a common teratogenic potential, although the structural requirements for activity remain obscure.
Coakley, ME, Rawlings, SJ, Brown, NA
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Kidney tubular injury induced by valproic acid: systematic literature review. [PDF]
, 2023 BACKGROUND Valproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches. It has also been implicated as a cause of a kidney tubular injury.
Barbara Goeggel Simonetti +15 more
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The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo [PDF]
, 2008 Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical ...
Eva Juengel +13 more
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New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
P. D. Soldato +17 more
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