Results 201 to 210 of about 2,544,276 (249)

Prenatal valproic acid exposure alters striatal proteomic signatures associated with autism spectrum disorder in mice. [PDF]

open access: yesTransl Psychiatry
Jo EH   +10 more
europepmc   +1 more source

Volumetric Microsampling for Patient‐Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Accurate drug concentration measurement is essential for precision pharmacotherapy, but conventional therapeutic drug monitoring (TDM) requires venous sampling, increasing patient burden, and potentially limiting participation in TDM and model‐informed precision dosing (MIPD).
Hari Prabhath Tummala   +5 more
wiley   +1 more source

Revisiting Enzyme Replacement Therapy for Aspartylglucosaminuria: Truncated Phosphotransferase Enhances Mannose‐6‐Phosphorylation and Cellular Uptake of Aspartylglucosaminidase

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by a deficiency of aspartylglucosaminidase (AGA), a hydrolase involved in the degradation of N‐glycosylated proteins. Currently, no approved therapies are available for AGU. Development of enzyme replacement therapy (ERT) for AGU has been hampered by the complex proteolytic ...
Antje Banning   +3 more
wiley   +1 more source

Neurocardiology: Brain–Heart Interactions in the Heart

open access: yesMedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang   +3 more
wiley   +1 more source

Epilepsy‐Related Psychosis in Drug‐Resistant Epilepsy With Nonconvulsive Status Epilepticus and Difficult Antipsychotic Titration: A Case Report

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Electroclinical findings supported diazepam‐responsive nonconvulsive status epilepticus (NCSE) in an older patient with drug‐resistant epilepsy and psychosis. After phenytoin treatment, continuous EEG helped monitor recurrence. Later symptoms were most consistent with interictal psychosis with a possible alternative psychosis component, emphasizing ...
Wataru Omori   +4 more
wiley   +1 more source

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