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The pharmacogenomics of valproic acid [PDF]
Journal of Human Genetics, 2017 Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. Adverse effects of valproic acid are rare, but hepatotoxicity is severe in particular in those younger than 2 years old and polytherapy.
Zanling Zhang +5 more
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Pediatric Blood & Cancer, 2020
To study the efficacy and tolerability of valproic acid (VPA) and radiation, followed by VPA and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high‐grade glioma (HGG).
J. Su +10 more
semanticscholar +1 more source
To study the efficacy and tolerability of valproic acid (VPA) and radiation, followed by VPA and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high‐grade glioma (HGG).
J. Su +10 more
semanticscholar +1 more source
Drug and chemical toxicology (New York, N.Y. 1978), 2020
Oxidative stress and mitochondrial dysfunction have been associated with valproic acid (VPA) induced neurotoxicity. Mitochondria are vulnerable to oxidative damage and are also a major source of superoxide free radicals.
A. Salimi +4 more
semanticscholar +1 more source
Oxidative stress and mitochondrial dysfunction have been associated with valproic acid (VPA) induced neurotoxicity. Mitochondria are vulnerable to oxidative damage and are also a major source of superoxide free radicals.
A. Salimi +4 more
semanticscholar +1 more source
Prescribing Practices of Valproic Acid for Agitation and Delirium in the Intensive Care Unit
The Annals of Pharmacotherapy, 2020Background Analgesics, sedatives, and antipsychotics are commonly prescribed for agitation and delirium in the intensive care unit (ICU), but their use is limited by adverse effects and lack of efficacy.
Nicholas J. Quinn +4 more
semanticscholar +1 more source
Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid
Epilepsia, 2020In January 2019, a new plant‐derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox‐Gastaut syndrome or Dravet syndrome.
Nancy A McNamara +10 more
semanticscholar +1 more source
JAMA: The Journal of the American Medical Association, 1979
To the Editor.— We are writing in regard to the article "Valproic Acid (Depakene): A New Anticonvulsant Agent" (240:2190, 1978), in which Lewis presented a succinct review of the literature relative to the efficacy and toxicity of this drug. His conclusion that valproic acid "is most effective in absence seizures (simple and complex)" and "has ...
Samuel Livingston +3 more
openaire +3 more sources
To the Editor.— We are writing in regard to the article "Valproic Acid (Depakene): A New Anticonvulsant Agent" (240:2190, 1978), in which Lewis presented a succinct review of the literature relative to the efficacy and toxicity of this drug. His conclusion that valproic acid "is most effective in absence seizures (simple and complex)" and "has ...
Samuel Livingston +3 more
openaire +3 more sources
Valproic Acid in the Management of Delirium
American Journal of Hospice and Palliative Medicine®, 2021Context: Antipsychotics and benzodiazepines do not improve delirium. Valproic acid (VPA) has been used recently to treat agitation in delirium. Objectives: To review the evidence for VPA in the management of Delirium. Methods: Systematic review. English language, age 19 and above, from 1946 to January 12, 2021. Mesh Terms: “Valproic acid”, “valproate”,
Carlos Fernandez Cuartas, Mellar Davis
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Teratology, 1987
AbstractValproic acid use during pregnancy results in an absolute risk for spina bifida of 1–2%. This increased risk is comparable to the recurrence risk for neural tube defects and warrants informed counselling and access to prenatal diagnosis.
Sever Le, Lammer Ej, Oakley Gp
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AbstractValproic acid use during pregnancy results in an absolute risk for spina bifida of 1–2%. This increased risk is comparable to the recurrence risk for neural tube defects and warrants informed counselling and access to prenatal diagnosis.
Sever Le, Lammer Ej, Oakley Gp
openaire +3 more sources
Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update.
Current pharmaceutical design, 2019BACKGROUND Valproic acid (VPA) as a widely used primary medication in the treatment of epilepsy is associated with reversible or irreversible hepatotoxicity.
Hongli Guo +9 more
semanticscholar +1 more source