Results 131 to 140 of about 167,491,100 (260)
Forest Valuation under Carbon Pricing: A Real Options Approach
, 2009 Emissions trading schemes are increasingly being adopted to combat climate change. New Zealand created the world?s first ?all sectors all gases? such scheme in 2008, awarding tradable credits for carbon sequestration and imposing liabilities for ...
Evans, Lewis +2 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Quantitative valuation of platform technology based intangibles companies [PDF]
In the course of raising external equity, e.g. from venture capitalists, a quantitative valuation is usually required for entrepreneurial ventures. This paper examines the challenges of quantitatively valuing platform technology based entrepreneurial ...
Schraml, Stephanie +2 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Decomposing and valuing callable convertible bonds: a new method based on exotic options [PDF]
In the framework of Black-Scholes-Merton option pricing models, by employing exotic options instead of plain options or warrants, this paper presents an equivalent decomposition method for usual Callable Convertible Bonds (CCB). Furthermore, the analytic
Wu, Chong-Feng, Zhou, Qi-Yuan, Feng, Yun
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
On the valuation and incentive effects of executive cash bonus contracts [PDF]
Executive compensation packages are often valued in an inconsistent manner: while employee stock options (ESOs) are typically valued ex-ante, cash bonuses are valued ex-post.
Lionel Martellini, Branko Urosevic
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Expanding Quantitative Medicines' Reach: Systems and Methods to Enhance R&D Productivity and Decision-Making in the Agentic-Era. [PDF]
Clin Transl SciCorrigan BW +8 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Other title: Evaluating the Revenue Impact of Machinery and Equipment Classification and Valuation
, 2013 application/pdf; "February 20, 2013."; "Division of Property Valuation on the Legislative Post Audit Report."; Presentation before the Kansas Legislature, House Taxation Committee, by the Division of Property Valuation, Kansas ...
Kansas. Division of Property Valuation.
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