KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Giga-Investments: Modelling the Valuation of Very Large Industrial Real Investments
In this doctoral dissertation characteristics of very large industrial real investments (VLIRI) are investigated and a special group of VLIRI is defined as giga-investments.
Collan, Mikael
core
The Valuation of Employee Stock Options
, 2007 員工認股權給予員工一權利，約定員工於一定期間內，得依約定價格認購特定數量之公司股份，訂約後由公司發給員工認股權憑證。由此可知，員工認股權為一買權，但是由於其有一些特殊的性質，使其不能使用傳統的選擇權訂價模式評價。在此篇論文當中，將會使用二元樹做為基底模型，並針對稀釋效果、員工可分次執行認股權以及狀態相依員工離職率對二元樹模型做調整。最後，將會以調整過後的模型和現今數個較具代表性的模型相比較。The unique characteristics of employee stock options make
Liao, Feng-Yu, 廖鳳玉
core
Unlocking the financing potential of forest-based carbon assets: a valuation framework for pledge lending under uncertainty in China. [PDF]
Sci RepZhang Y, Zhang J.
europepmc +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
A Note on Valuation of Companies with Growth Opportunities [PDF]
Each company faces day to day investment opportunities. Just by staying in business the company is taking a decision of reinvesting. The question arising for those managers who have the responsability of allocating capital is the criteria they should use
José Pablo Dapena
core
Preference-based scoring algorithm to estimate societal utilities based on the patient-reported experience of cognitive impairment in schizophrenia (PRECIS) instrument. [PDF]
Qual Life ResHoogendoorn M +5 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Valuation of Exchangeable Convertible Bonds [PDF]
This paper provides a structural valuation model for exchangeable convertible bonds, since such bonds are widespread by now. The model is solved through the Hopscotch finite difference method.
Marco Realdon
core
The Canine Search and Adoption Decision Process: A Conceptual Framework for Companion Pet Shelter Adoption. [PDF]
Animals (Basel)Minnis L, Davis DB.
europepmc +1 more source