Results 171 to 180 of about 14,588 (268)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

In Search of a Neural Mechanism for Domain-General Value Comparison in Decision Making. [PDF]

J Neurosci
Samara A, Zada Z.
europepmc   +1 more source

A Real Options Approach to Amenity Valuation the Role of Uncertainty and Risk Aversion

, 2015
Andreas Mense
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Estimating the impact of pill burden on health utilities in hemodialysis therapy. [PDF]

Sci Rep
Shimoda H, Taniguchi M, Yamamoto S, Igarashi A, Tokunaga S, Hanada K, Tashiro N, Murata T, Asada S.   +8 more
europepmc   +1 more source

The Valuation and Informational Content of Options on Crude-Oil Futures Contracts

, 2009
J. Glenn Andrews, Ehud I. Ronn
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Prioritization of Users in Ecosystem Service Valuation: Implications for the Design of Differentiated Conservation Policies. [PDF]

Ecol Evol
Sánchez Toledano BI, Bravo MB, Vázquez RG, López Santiago MA.   +3 more
europepmc   +1 more source

The Intuition Behind Option Valuation: A Teaching Note [PDF]

, 2002
Thomas A. Grossman, Stephen G. Powell, Kent L. Womack, Ying Zhang   +3 more
openalex  

Optimal Valuation of Variable Annuity Guaranteed Lifetime Withdrawal Benefits with Embedded Top-up Option [PDF]

Budhi Surya
openalex   +1 more source