Results 51 to 60 of about 115,970 (304)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An Empirical Investigation of Purchasing Power Parity for a Transition Economy - Cambodia [PDF]

This study has found an empirical support of Purchasing Power Parity (PPP) theory for an East Asia transition economy – Cambodia. It is based on the results of cointegration among KHR/USD, Cambodia CPI, and world CPI over the monthly period May 2001 ...
Tuck Cheong Tang, Venus Khim-Sen Liew
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

THE INFLUENCE OF PRICE PERCEPTION AND RISK PERCEPTION ON PURCHASE INTENTION AND PURCHASE DECISIONS OF CUSTOMS-PAID IPHONES IN PEKANBARU

Indonesian Interdisciplinary Journal of Sharia Economics
This study aims to analyze the influence of price perception and perceived risk on purchasing decisions of customs-paid iPhones, with purchase intention as a mediating variable in Pekanbaru.
Bayu Pramudia, Rahmat Setiawan
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Factors in patients’ experience of hospital care: Evidence from California, 2009–2011

Patient Experience Journal, 2014
The use of measures of patient-centered care to evaluate hospital care is mandated by The Patient Protection and Affordable Care Act of 2010. Using three years of data from 315 California acute-care hospitals and data collected from patients via the ...
Edmund Becker, Jason Hockenberry, Jaeyong Bae, Ariel Avgar, Sandra Liu, Ira Wilson, Arnold Milstein   +6 more
doaj  

PENGARUH IKLAN DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN MELALUI MINAT BELI SEBAGAI VARIABEL INTERVENING PADA UD ANUGERAH GRESIK

Journal of Management and Accounting
This research aims to determine the influence of advertising and price on purchasing interest, the influence of advertising and price on purchasing decisions, the influence of advertising on purchasing decisions through purchasing interest as an ...
Ali Muhajir
doaj   +1 more source

PENGARUH NILAI YANG DIANUT TERHADAP PREFERENSI DAN PERILAKU PEMBELIAN BUAH-BUAHAN

Jurnal Ilmu Keluarga dan Konsumen, 2011
  This research was based on theoretical and empirical reviews to explain the effect of values on the preferences and purchasing behavior of fruits. This research was performed by providing questionnaires to 162 college students by convenience sampling ...
Za'iemah Asy Syifa, Hartoyo Hartoyo
doaj   +1 more source

Value-Based Purchasing: Implications for Hematology. [PDF]

Am Health Drug Benefits, 2016
Doyle C.
europepmc   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source