Results 51 to 60 of about 765,531 (338)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Establishing a Health Technology Assessment Evidence Ecosystem in India’s Pradhan Mantri Jan Arogya Yojana

Health Systems & Reform, 2023
The introduction of the Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (AB PM-JAY) scheme in India was a significant step toward universal health coverage. The PM-JAY scheme has made notable progress since its inception, including increasing the number
Shankar Prinja, Yashika Chugh, Nidhi Gupta, Vipul Aggarwal   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Letter to the Editor: The Value of Value-Based Purchasing [PDF]

, 2005
No abstract ...
Greene, Robert A.
core   +1 more source

A prescriptive approach to qualify and quantify customer value for value-based requirements engineering

, 2013
Recently, customer-based product development is becoming a popular paradigm. Customer expectations and needs can be identified and transformed into requirements for product design with the help of various methods and tools.
Bayus B., Claude Baron, EIA 632, Guillaume Auriol, Hakki Eres, Hauser J.R., Keeney R.L., Keeney R.L., Pahl G., Scanlan J., Sen A., Ulrich K., Xinwei Zhang   +12 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

THE STRATEGIC ROLE OF PURCHASING MANAGEMENT IN THE KNOWLEDGE BASED SOCIETY [PDF]

Management & Marketing, 2012
We are now at the beginning of a new era, the industrial society has become a service society and is on the way to become an information and knowledge society. Because of the fearful competition on the marketplace, organizations are giving more attention
Corina POP SITAR
doaj  

Hospital value-based payment programs and disparity in the United States: A review of current evidence and future perspectives

Frontiers in Public Health, 2022
Beginning in the early 2010s, an array of Value-Based Purchasing (VBP) programs has been developed in the United States (U.S.) to contain costs and improve health care quality.
Hyunmin Kim, Hyunmin Kim, Asos Mahmood, Asos Mahmood, Asos Mahmood, Noah E. Hammarlund, Cyril F. Chang   +6 more
doaj   +1 more source

THE IMPACT OF STRATEGIC PURCHASING TO THE SUPPLIER INVOLVEMENT THROUGH COMMUNICATION, COORDINATION AND COLLABORATION IN SMAAL AND MEDIUM ENTERPRISES [PDF]

, 2009
In recent times, the theory of purchasing and supply operations has been widely studied under a variety of labels and for a number of reasons. Realizing competitive advantage from organizational alignment and relation to materials supply is for a form of
Tarigan, Zeplin Jiwa Husada
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source