Results 121 to 130 of about 6,433,039 (224)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Herpes Zoster Risk Among US Cancer Patients Following Initiation of Immunosuppressive Therapy

Cancer Management and Research
Justin Gatwood,1 Yong Zhu,2 Andrea Steffens,2 Stephanie J Gallagher,2 Mary C DuCharme,2 Kristin J Moore,2 Nikita Stempniewicz1 1GSK, Philadelphia, PA, USA; 2Value and Evidence Solutions, Optum Life Sciences, Eden Prairie, MN, USACorrespondence: Justin ...
Gatwood J, Zhu Y, Steffens A, Gallagher SJ, DuCharme MC, Moore KJ, Stempniewicz N   +6 more
doaj  

Speculation as Surplus-Value

, 2019
Speculation is an artist’s capital, enabling the emergence of the new. This is art’s capacity to bring about new frames of reference—new kinds of questions, experiences, events or encounters— to leverage difference in order to open onto an indeterminate ...
Andrea Eckersley (18025996), Terri Bird (19976409)   +1 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A Method for Adjusting EQ-5D-3L Health State Utilities for Cross-Country Use: Application of a Novel US-to-UK Utility Mapping Approach

ClinicoEconomics and Outcomes Research
Abdul Jabbar Omar Alsaleh,1 Jerome Msihid,2 Elisheva Lew,3 Charlie Nicholls4 1Health Economics and Value Assessment, Sanofi, Milan, Italy; 2Health Economics and Value Assessment, Sanofi, Gentilly, France; 3Health Economics and Value Assessment, Sanofi ...
Omar Alsaleh AJ, Msihid J, Lew E, Nicholls C   +3 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Values and value

This dissertation examines how moral value is constructed, performed, and rendered exchangeable on a market for Diversity, Equity, and Inclusion (DEI) consulting in Denmark. While DEI work is often framed as a morally driven effort to improve organizational life, the growing importance of external actors influencing organizational DEI agendas raises ...
openaire   +3 more sources

Value Superiority

, 2015
Suppose that A and B are two kinds of goods such that more of each is better than less. A is strongly superior to B if any amount of A is better than any amount of B. It is weakly superior to B if some amount of A is better than any amount of B.
Rabinowicz, Wlodek,, Arrhenius, Gustaf
core