Results 121 to 130 of about 26,602,709 (313)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Drugs - Real World OutcomesBackground Disease-modifying anti-rheumatic drugs (DMARDs), since their introduction in 1990, have revolutionized the management of rheumatoid arthritis.
Samuel K. Peasah +7 more
doaj +1 more source
Frontiers in PediatricsIntroductionThe widespread implementation of pneumococcal conjugate vaccines (PCVs) into pediatric national immunization programs (NIPs) across Latin American countries has substantially reduced pneumococcal disease burden.
Sophie Warren +8 more
doaj +1 more source
Using Effect Size-or Why the P Value Is Not Enough.
Journal of Graduate Medical Education, 2012 Gail M. Sullivan, R. Feinn
semanticscholar +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BMC Musculoskeletal DisordersBackground Degenerative disc disease (DDD) is a common disorder that can lead to chronic lower back pain (CLBP). The Oswestry Disability Index (ODI) is a well-established instrument for diseases of the lumbar spine and lower back pain (LBP), covering ...
John H. Powers +4 more
doaj +1 more source
VALUE CREATION AND RESOURCE-BASED VIEW
, 2010 A PRESENTATION OF LINKAGES BETWEEN VALUE CREATION STUDIES AND RESOURCE-BASED ...
SCIARELLI, MAURO
core
Making Space, adding value; locating and defining the 'creative space' of spatial production. [PDF]
, 2017 Ideas are born within a mental ‘creative space’ and are valued across creative disciplines. However, as architectural practice frantically responds to demands of time, economy and style, the value of such ‘creativity’ and ‘space for creativity’ is often ...
Evans, E.
core