Results 141 to 150 of about 26,602,709 (313)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An integrative framework of value [PDF]

The concept of value has been discussed for over 2000 years with various nuanced meanings. It was a focus of concern for Plato and Aristotle, and Adam Smith (1776) dealt extensively with value in The Wealth of Nations.
Smith, Laura A., Ng, Irene C. L.
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A Method for Adjusting EQ-5D-3L Health State Utilities for Cross-Country Use: Application of a Novel US-to-UK Utility Mapping Approach

ClinicoEconomics and Outcomes Research
Abdul Jabbar Omar Alsaleh,1 Jerome Msihid,2 Elisheva Lew,3 Charlie Nicholls4 1Health Economics and Value Assessment, Sanofi, Milan, Italy; 2Health Economics and Value Assessment, Sanofi, Gentilly, France; 3Health Economics and Value Assessment, Sanofi ...
Omar Alsaleh AJ, Msihid J, Lew E, Nicholls C   +3 more
doaj  

Hematological and biochemical responses to three doses of caffeine during the CrossFit® workout: a randomized, double-blind, crossover trial. [PDF]

J Int Soc Sports Nutr
Główka N, Podgórski T, Malik J, Nowaczyk PM, Durkalec-Michalski K.   +4 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Values and value

This dissertation examines how moral value is constructed, performed, and rendered exchangeable on a market for Diversity, Equity, and Inclusion (DEI) consulting in Denmark. While DEI work is often framed as a morally driven effort to improve organizational life, the growing importance of external actors influencing organizational DEI agendas raises ...
openaire   +3 more sources

Value Capture from Organizational Advantages and Sustainable Value Creation [PDF]

The impact of firm value capture strategies on the sustainability of the value creation process as a whole has been little discussed in the literature.
Pitelis, Christos
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source