Results 121 to 130 of about 476,055 (308)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Global value chains participation and environmental degradation in SAARC economies [PDF]
The rapid rise in the globalization of production processes, knowledge spillovers, grave environmental concerns, and sustainable development goals have attracted researchers and policymakers to explore the causes and consequences of these ...
Nawaz, Ahmad, Rahman, Mohammad Mafizur
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
How does income inequality affect energy rebound effect? Empirical evidence from China
Sustainable FuturesReducing income inequality and controlling energy rebound are both important targets of the Sustainable Development Goals (SDGs). When we strive for realizing these goals, is there a win-win result between them or a trade-off?
Maliyamu Abudureheman +2 more
doaj +1 more source
, 2023 These slides were used during the Stakeholders’ Consultation Meeting on Agrifood value chains in Odisha Challenges and Opportunities, at Auditorium, Department of Agriculture & Farmers' Empowerment (Krushi Bhavan) Bhubaneswar, Odisha, India on 29 ...
Nandi, Ekadashi +11 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
FoodsAchieving more sustainable production in emerging biomanufacturing sectors depends not only on technological innovation but also on how production systems are organized, governed, and scaled.
Germano Glufke Reis +2 more
doaj +1 more source
A value chain and cluster perspective on competitiveness of European fresh vegetable production – Case studies from Germany, Italy, and Spain [PDF]
In the present study we combine cluster theory with a value chain approach, with the aim of discovering elements of the European fresh vegetable business that could enable local producers to gain competitive advantages in a global market.
Bettina Riedel
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source