Results 171 to 180 of about 583,925 (313)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Value co-creation between SME suppliers and large customers in the UK organic food sector.

As the distinction in roles of production by suppliers and consumption by customers become blurred, concomitantly there is increasing interest to understand the process of how value is co-created through interaction in business relationships.
Ngugi, Isaac K.
core  

Unicorns transforming the practice of urology: value creation and allocation in the digital age. [PDF]

World J Urol
Erben P, Rodler S, Turki AT, Witzsch U, Thielscher C.   +4 more
europepmc   +1 more source

Discovering the Value Creation System in IoT Ecosystems. [PDF]

Sensors (Basel), 2021
Lopez CA, Castillo LF, Corchado JM.
europepmc   +1 more source

The value of lithography in artistic creation

Studiul artelor şi culturologie: istorie, teorie, practică
In the carried out research is highlighted the role and contribution of lithography as an original technique of multiplication, which contributed to the development of graphic art. Focusing on the presentation of the technical characteristics, the author pleads for bringing back the interest of plastic artists and graphic design students towards this ...
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The data-driven decision-making, sustainable value creation, and international firm performance: Micro-level evidence based on AI language models. [PDF]

PLoS One
Xu M, Lu B.
europepmc   +1 more source

Innovating agri-food business models after the Covid-19 pandemic: The impact of digital technologies on the value creation and value capture mechanisms. [PDF]

Technol Forecast Soc Change, 2023
Mancuso I, Messeni Petruzzelli A, Panniello U.   +2 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Framework to identify innovative sources of value creation from platform technologies. [PDF]

Proc Natl Acad Sci U S A
Jones CH, Beitelshees M, Hill A, Griffiths D, Murphy M, Kapadia K, Dolsten M, True JM.   +7 more
europepmc   +1 more source