Results 31 to 40 of about 1,399,859 (221)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Particle Physics Probes Of Extra Spacetime Dimensions

, 2002
The possibility that spacetime is extended beyond the familiar 3+1-dimensions has intrigued physicists for a century. Indeed, the consequences of a dimensionally richer spacetime would be profound.
Casimir HGB, Caso C, JoAnne Hewett, Kaluza T, Kappadath SC, Maria Spiropulu, Mitrofanov VP, Nordström G   +7 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Hysteresis, Avalanches, and Disorder Induced Critical Scaling: A Renormalization Group Approach

, 1995
We study the zero temperature random field Ising model as a model for noise and avalanches in hysteretic systems. Tuning the amount of disorder in the system, we find an ordinary critical point with avalanches on all length scales. Using a mapping to the
A. A. Middleton, A. A. Middleton, A. A. Middleton, A. A. Vladimirov, A. Aharony, A. Berger, A. Berger, A. Brass, A. J. Bray, A. Maritan, A. P. Young, A. P. Young, A. T. Ogielski, A. W. Pang, A. Zippelius, A. Zippelius, B. Koiller, B. Koiller, B. Tadic, C. Bender, C. De Dominicis, C. De Dominicis, C. Domb, C. F. Richter, C. M. Coram, C. Myers, C. Myers, D. Dhar, D. Ertaş, D. Ertaş, D. I. Kazakov, D. J. Amit, D. J. Wallace, D. Jiles, D. P. Belanger, D. S. Fisher, D. S. Fisher, D. Sornette, D. Sornette, D. Stauffer, E. Brézin, E. Brézin, E. J. Ding, E. Vives, E. Vives, E. Vives, F. Preisach, G. Bertotti, G. Bertotti, G. Bertotti, G. Bertotti, G. Grinstein, G. L. Vasconcelos, G. Montalenti, G. Parisi, G. Parisi, G. Parisi, H. Bittel, H. Ji, H. Kleinert, H. Rieger, H. Sompolinsky, H. Sompolinsky, I. D. Mayergoyz, J. Bricmont, J. Bricmont, J. C. Le Guillou, J. C. McClure, Jr., J. F. Joanny, J. J. Binney, J. M. Carlson, J. M. Yeomans, J. P. Sethna, J. P. Sethna, J. P. Sethna, J. Phys, J. S. Urbach, J. T. Chayes, J. Villain, J. Villain, J. Z. Imbrie, J. Z. Imbrie, J. Z. Imbrie, J. Zemmouri, J. Zinn-Justin, James P. Sethna, K. Christensen, K. Dahmen, K. Dahmen, K. G. Wilson, K. H. Fischer, K. K. Babcock, K. L. Babcock, K. L. Babcock, K. M. Godshalk, K. P. O'Brien, K. P. O'Brien, K. Stierstadt, Karin Dahmen, L. H. Ryder, L. Pietronero, L. V. Meisel, M. Blume, M. Cieplak, M. Cieplak, M. E. J. Newman, M. E. J. Newman, M. Fisher, M. Krasnoselskii, M. Mézard, M. Mézard, M. P. Lilly, M. Rao, M. Schwartz, N. G. van Kampen, N. Goldenfeld, N. Martys, N. Martys, N. W. Ashcroft, O. Narayan, O. Narayan, O. Narayan, O. Narayan, O. Narayan, O. Perković, P. B. Thomas, P. Bak, P. Bak, P. C. Clapp, P. C. Hemmer, P. C. Hohenberg, P. C. Martin, P. J. Cote, P. Ramond, R. B. Griffiths, R. Bausch, R. Burridge, R. L. Smith, R. Lenormand, S. Chikazumi, S. Field, S. K. Ma, S. N. Coppersmith, T. Nattermann, T. Nattermann, T. Nattermann, U. C. Täuber, U. Krey, U. Krey, U. Krey, U. Lieneweg, U. Lieneweg, V. M. Rudyak, V. M. Rudyak, V. Raghavan, W. Wu, Z. Olami   +156 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Breakdown of Conformal Invariance at Strongly Random Critical Points

, 2000
We consider the breakdown of conformal and scale invariance in random systems with strongly random critical points. Extending previous results on one-dimensional systems, we provide an example of a three-dimensional system which has a strongly random ...
A. M. Polyakov, B. L. Altshuler, B. L. Altshuler, B. Shapiro, C. Dasgupta, C. Mudry, D. G. Shelton, D. S. Fisher, D. Slepian, F. J. Dyson, I. I. Kogan, J. Polchinski, K. Efetov, L. Balents, M. B. Hastings, M. C. Wang, M. Janssen, O. Motrunich, P. W. Brouwer, S. L. Sondhi, S. N. Majumdar, T. D. Lee, T. W. Burkhardt, V. Gurarie, Y. G. Sinai   +24 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Recent Progress in Spin Glasses

, 2004
We review recent findings on spin glass models. Both the equilibrium properties and the dynamic properties are covered. We focus on progress in theoretical, in particular numerical, studies, while its relationship to real magnetic materials is also ...
Kawashima, N., Rieger, H.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source