Results 51 to 60 of about 1,399,859 (221)

Numerical tests of AdS/CFT at strong coupling

, 2008
We study various correlation functions (two and three point functions) in a large $N$ matrix model of six commuting matrices with a numerical Monte Carlo algorithm.
David Berenstein, E. Witten, G. ’t Hooft, J. M. Maldacena, Jun S. Liu, Randel Cotta, Rodrigo Leonardi, S. Corley, S. Lee   +8 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Non-vanishing boundary effects and quasi-first order phase transitions in high dimensional Ising models

, 2010
In order to gain a better understanding of the Ising model in higher dimensions we have made a comparative study of how the boundary, open versus cyclic, of a d-dimensional simple lattice, for d=1,...,5, affects the behaviour of the specific heat C and ...
Aizenman, Aizenman, Aizenman, Balog, Binder, Blöte, Brezin, Brézin, Cea, Chen, Chen, Chen, Ferdinand, Fortuin, Heydenreich, Heydenreich, Häggkvist, Häggkvist, Häggkvist, K. Markström, Lai, Luijten, Luijten, Lundow, Lundow, Mon, Onsager, P.H. Lundow, Privman, Sokal, Stevenson, Touchette, van Hove, Wolff   +33 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Macroscopic Quantum Phenomena from the Correlation, Coupling and Criticality Perspectives

, 2011
In this sequel paper we explore how macroscopic quantum phenomena can be measured or understood from the behavior of quantum correlations which exist in a quantum system of many particles or components and how the interaction strengths change with energy
B L Hu, Balescu R, Balescu R, Baym G, C H Chou, Calzetta E, Calzetta E, Calzetta E, Chou C H, Guilini D, Habib S, Hu B L, Hu B L, Hu B L, Hu B L, Hu B L, Huang K, Hutchinson D A W, Jacobson T A, Kac M, Keldysh L V, Keldysh L V, Morgan S A, Pathria R K, Proukakis N P, Schwinger J, Spohn H, Y Subaşi   +27 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components

Public Health Research
Background Women who have additional social and care needs in pregnancy (e.g. social adversity, maternal depression and anxiety) are likely to produce high levels of stress hormones.
Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson   +18 more
doaj   +1 more source

Non-relativistic metrics from back-reacting fermions

, 2010
It has recently been pointed out that under certain circumstances the back-reaction of charged, massive Dirac fermions causes important modifications to AdS_2 spacetimes arising as the near horizon geometry of extremal black holes. In a WKB approximation,
Adams A, Adams A, Aninda Sinha, Anninos D, Balasubramanian K, Birrell N D, Clement G, Clement G, de Boer J Papadodimas K Verlinde E, Detournay S, Dileep P Jatkar, Faulkner T Liu H McGreevy J Vegh D, Hartnoll S A, Herzog C P, Herzog C P, Horava P Melby-Thompson C M, Horowitz G T, Imeroni E, Kachru S Liu X Mulligan M, Li W, Ling-Yan Hung, Liu H McGreevy J Vegh D, Maity D Sarkar S Sircar N Sathiapalan B Shankar R, Maldacena J, McGreevy J, Reinhard P G, Schafer T   +26 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source