Results 71 to 80 of about 14,679,274 (316)

Intervention for improvement the diet and physical activity of children and adolescents in Poland

Roczniki Panstwowego Zakladu Higieny, 2020
Background. The effects of a two-year educational Programme “Keep Balance” addressed to children and adolescents have been evaluated. Its purpose has been to implement the rules of proper nutrition and increasing the level of physical activity on the ...
Katarzyna Wolnicka, Jadwiga Charzewska, Anna Taraszewska, Renata Czarniecka, Joanna Jaczewska-Schuetz, Natalia Bieńko, Elżbieta Olszewska, Bożena Wajszczyk, Mirosław Jarosz   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Is there really a value in entrepreneurship education? [PDF]

, 2005
This paper considers whether entrepreneurship education has a value outside of the education institutions in which it takes place. The paper takes an indirect form of enquiry and argues that entrepreneurship education is driven by three factors; the ...
Willis, R., Adcroft, A., Dhaliwal, S.
core  

Care-seeking and delay of care during COPD exacerbations

npj Primary Care Respiratory Medicine, 2022
Patients who receive earlier treatment for acute exacerbations of chronic obstructive pulmonary disease (COPD) have a better prognosis, including earlier symptom resolution and reduced risk of future emergency-department visits (ED) or hospitalizations ...
Emily R. Locke, Jessica P. Young, Catherine Battaglia, Tracy L. Simpson, Ranak Trivedi, Carol Simons, John C. Fortney, Paul Hebert, Erik R. Swenson, Jeffrey Edelman, Vincent S. Fan   +10 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Value Propositions in Higher Education: an S-D logic view [PDF]

, 2011
Service-dominant (S-D) logic is portrayed by Vargo and Lusch (2008) as a "mindset", a way of examining exchange. Higher education as a whole is a context in which (S-D) logic might be explored yet has attracted comparatively little attention to date. In
Lynch, J., Chalcraft, D.
core  

What are People That Seek Care for Rotator Cuff Tendinopathy Experiencing in Their Daily Life?

Journal of Patient Experience, 2022
This qualitative study sought to answer three questions: What is it like to live with rotator cuff tendinopathy? What are the barriers and facilitators of a healthy lifestyle with an aging shoulder?
Chris Ulack PhD, Joel Suarez PhD, Laura Brown PhD, David Ring MD, PhD, Scott Wallace JD, MBA, Elizabeth Teisberg PhD   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source