Results 101 to 110 of about 7,419,285 (306)

Value Engineering Adoption’s Barriers and Solutions: The Case of Saudi Arabia’s Construction Industry

Buildings
Several developing countries around the globe have launched their future visions, which include concrete strategic plans that involve many kinds of mega-construction projects.
Abdullah M. Alhumaid, Abdulrahman A. Bin Mahmoud, Abdulmohsen S. Almohsen   +2 more
doaj   +1 more source

A theoretical model for design in Management science : the paradigm shift in the design profession for management as a constraint to management science as an opportunity [PDF]

, 2008
Design Management has changed greatly since 1990 Peter Gorb definition .The purpose of this paper is to synthetize the various models of Design Management and to explain their limits in front of the paradigm shift of the design profession, changing “from
Borja de Mozota, B
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Responsibility for managing values. The metaethical dilemma between normative absolutism and relativism

Journal of Responsible Innovation
This investigation discusses the implications of the two most fundamental counter-assumptions of axiology – normative relativism and anti-relativism (absolutism) – for managing values in the process of responsible research and innovation.
Jan Franciszek Jacko
doaj   +1 more source

STRATEGIC OUTLINES: BETWEEN VALUE AND DIGITAL ASSETS MANAGEMENT [PDF]

Enterprise content management leverages digital asset management to supportbusiness channel diversity. Business asset management technology is targeted to products and finalservices.
Alexandru Adrian Gavrila, Delia Babeanu, Valerica Mares   +2 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Case Study on Design Management: Inefficiencies and Possible Remedies [PDF]

, 2015
Delivering better products with a reduced lead time and less resources has become the primary focus of design management. The aim of this work is to revisit typical design management inefficiencies and discuss possible remedies for these problems.
Dave, Bhargav, Koskela, Lauri, Liias, Roode, Pikas, Ergo   +3 more
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Modeling Sustainable Earned Value Management (EVM) Under Grey Uncertain Conditions

Systems
The EVM method is an essential project management technique that compares the work done to the planned values (PVs) to identify project variances. However, the inherent uncertainties and possibilities in the project introduce uncertainty in the input ...
Lei Fan, Shima Mohseni Nejad, Morteza Bagherpour, Mohammad Reza Feylizadeh, Negar Karimi   +4 more
doaj   +1 more source