Results 101 to 110 of about 7,507,540 (309)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Value Management Implementation as Determinants of Overall Project Success: An Empirical PLS-SEM Study of Building Projects in Oman

Buildings
The construction sector in developing countries continues to face persistent challenges related to cost overruns, projects delays, and compromised quality performance.
Noumer Alazaiza, Mohd Zakwan Ramli, Tahra Al Maskari, Daud Mohamad   +3 more
doaj   +1 more source

The Value of Information in Invasive Species Management [PDF]

Resource /Energy Economics and Policy,
Haight, Robert G., Homans, Frances R., Mehta, Shefali V.   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Properties Exploring and Information Mining in Consumer Community Network: A Case of Huawei Pollen Club

Complexity, 2018
Substantial changes took place in the role of consumers in the supply chain with the development of practices. They became creators from consumers of product values.
Qingchun Meng, Zhen Zhang, Xiaole Wan, Xiaoxia Rong   +3 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Value Engineering Adoption’s Barriers and Solutions: The Case of Saudi Arabia’s Construction Industry

Buildings
Several developing countries around the globe have launched their future visions, which include concrete strategic plans that involve many kinds of mega-construction projects.
Abdullah M. Alhumaid, Abdulrahman A. Bin Mahmoud, Abdulmohsen S. Almohsen   +2 more
doaj   +1 more source

Large-Value Payment System Design and Risk Management [PDF]

This article considers how wholesale (also often called large-value) payment systems can be organised, how they have evolved over recent decades and what are the forces currently at play in shaping settlement mechanisms.
Cronin, David
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Responsibility for managing values. The metaethical dilemma between normative absolutism and relativism

Journal of Responsible Innovation
This investigation discusses the implications of the two most fundamental counter-assumptions of axiology – normative relativism and anti-relativism (absolutism) – for managing values in the process of responsible research and innovation.
Jan Franciszek Jacko
doaj   +1 more source