Results 181 to 190 of about 13,432,161 (307)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Modern analysis of value theory

MODERN ANALYSIS OF VALUE THEORY Modern analysis of value theory (-
Fujimori, Y.
core   +1 more source

Exploring factors influencing medical specialty choice among undergraduates in The Gambia: a situated expectancy-value theory approach. [PDF]

BMC Med Educ
Bikay AN, Akpoveso OP, Nweke CJ, Ekeoma EC, Tambe PB, Kabiru A.   +5 more
europepmc   +1 more source

Modeling multivariate cyber risks: deep learning dating extreme value theory. [PDF]

J Appl Stat, 2023
Zhang Wu M, Luo J, Fang X, Xu M, Zhao P.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Reproductive Value as Part of the Shadow Price of Population [PDF]

The reproductive value (see Fisher 1930) arises as part of the shadow price of the population in a large class of age-structured optimal control models.Reproductive value, distributed optimal control theory, McKendrick equation, shadow price, indirect ...
Michael Kuhn, Stefan Wrzaczek, Alexia Prskawetz, Gustav Feichtinger   +3 more
core  

Psychological drivers and barriers affecting students' sustained usage intention of AIGC tools in educational settings: an integrated perspective of Uses and Gratifications Theory and Perceived Value Theory. [PDF]

Front Psychol
Huang Q, Xu J, Zhang R, Song G.
europepmc   +1 more source

Modeling of the air temperature using the Extreme Value Theory for selected biomes in Mato Grosso do Sul (Brazil). [PDF]

Stoch Environ Res Risk Assess, 2022
Dos Reis CJ, Souza A, Graf R, Kossowski TM, Abreu MC, de Oliveira-Júnior JF, Fernandes WA.   +6 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Multiple sources and student engagement in the smart classroom: the mediating role of foreign language enjoyment under control-value theory. [PDF]

Front Psychol
Wu J.
europepmc   +1 more source