Results 201 to 210 of about 4,008,475 (239)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
International Journal of Game Theory, 2003 The existence of a value of norm 1 on the spaces \('NA\) and \('AN\), the closure in the variation distance of the linear space spanned by all games \(f\circ\mu\), where \(\mu\) is a non-atomic, non-negative finitely additive measure of mass 1 and \(f\) a real-valued function on \([0,1]\) which satisfies a much weaker continuity at zero and one.
Jean-Francois Mertens, Abraham Neyman
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‘Value, values and valued’: a tripod for organisational ethics
Journal of Medical Ethics, 2021Public benefit corporations are National Health Service, that is, state, entities whose function to provide healthcare in discharge of public duties. If we regardvalue as the output of such organisations, it seems logical to connect the values of the organisation to thevalue produced by such organisations. But, on closer examination there are competing
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The Design Journal, 2019
The everyday expression, ‘herding cats’ comes to mind when attempting to communicate the meaning of design in terms of ‘value’, ‘values’ and ‘valuing’.
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The everyday expression, ‘herding cats’ comes to mind when attempting to communicate the meaning of design in terms of ‘value’, ‘values’ and ‘valuing’.
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Poem, 2015
Values are — as the word suggests — the things in life that we most value. Whilst our opinions blow with the wind and our attitudes change over time, our values and beliefs tend to remain fixed throughout our lives.
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Values are — as the word suggests — the things in life that we most value. Whilst our opinions blow with the wind and our attitudes change over time, our values and beliefs tend to remain fixed throughout our lives.
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Journal of Health Communication, 2008
Nearly a century ago in 1913, Frederick Gates challenged the Rockefeller Foundation's board at its first meeting: “If science and education are the brain and nervous system of civilization, health ...
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Nearly a century ago in 1913, Frederick Gates challenged the Rockefeller Foundation's board at its first meeting: “If science and education are the brain and nervous system of civilization, health ...
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CFA Institute Magazine, 2006
While the legal system may ultimately punish egregious behavior in the financial markets, if all market participants followed the CFA Institute Code and Standards, such enforcement would not be needed.
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While the legal system may ultimately punish egregious behavior in the financial markets, if all market participants followed the CFA Institute Code and Standards, such enforcement would not be needed.
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