Results 241 to 250 of about 10,025,038 (290)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Missing comparability: When genomic selection faces field variability. A case study in soybeans. [PDF]

Plant Genome
Caballero E, Garcia-Abadillo J, Jarquin D.   +2 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Hyperpolarized MRI Detects Increased [1-¹³C]Pyruvate Metabolism in Early Liver Regeneration. [PDF]

NMR Biomed
Kjærgaard U, Lund A, Bertelsen LB, Hansen ESS, Andersen KH, Ringgaard S, Nyengaard JR, Mortensen FV, Laustsen C.   +8 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Developing new energy intake reference values for the Saudi population. [PDF]

BMC Nutr
Alhumaidan O, Almajwal A, Alsaif M.
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Validation of the ECTemp™ algorithm in construction workers: a comparison of photoplethysmography smartwatch and chest strap heart rate monitors. [PDF]

Environ Res Commun
Lignier MJ, Tourula E, Raef JM, Specht JW, Bailly A, Hite MJ, Walker C, Sweitzer L, Yoder HA, Garcia S, Khandpekar O, Zoh RS, Glaser J, Wegman DH, Amorim F, Schlader ZJ.   +15 more
europepmc   +1 more source

Refining Niche Metric Calculations: A Modified Weighting Approach to Colwell and Futuyma's Method. [PDF]

Bull Math Biol
Özkan K, Özdemir S, Muys B, Doğan S.
europepmc   +1 more source

Effects of Norbixin on Growth Performance, Immunomodulation, Antioxidant Systems, and Metabolic Alterations in the Oriental River Prawn (Macrobrachium nipponense): An Integrative Analysis. [PDF]

Vet Med Sci
Ettefaghdoost M, Haghighi H, Haghdoost A.   +2 more
europepmc   +1 more source