Results 41 to 50 of about 195,389 (268)

Valve-in-Valve Transcatheter Aortic Valve Implantation for Degenerated Bioprosthetic Heart Valves

JACC: Cardiovascular Interventions, 2011
We sought to analyze outcomes of patients with degenerated surgically implanted bioprosthetic heart valves undergoing valve-in-valve (viv) transcatheter aortic valve implantation (TAVI).Redo cardiac surgery for degenerated bioprosthetic heart valves is associated with increased risks, particular in elderly patients with comorbidities.
Eggebrecht, Holger, Schäfer, Ulrich, Treede, Hendrik, Boekstegers, Peter, Babin-Ebell, Jörg, Ferrari, Markus, Möllmann, Helge, Baumgartner, Helmut, Carrel, Thierry, Kahlert, Philipp, Lange, Philipp, Walther, Thomas, Erbel, Raimund, Mehta, Rajendra H., Thielmann, Matthias Klaus, Schäfer, Ulrich   +15 more
openaire   +4 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Conduction Abnormalities After Transcatheter Aortic Valve Replacement

US Cardiology Review, 2019
Transcatheter aortic valve replacement (TAVR) has been established as a therapeutic option for patients with severe symptomatic aortic stenosis who are of intermediate or higher surgical risk.
Somsupha Kanjanauthai, Kabir Bhasin, Luigi Pirelli, Chad A Kliger   +3 more
doaj   +1 more source

Investigation of cylinder deactivation and variable valve actuation on gasoline engine performance [PDF]

, 2014
Increasingly stringent regulations on gasoline engine fuel consumption and exhaust emissions require additional technology integration such as Cylinder Deactivation (CDA) and Variable valve actuation (VVA) to improve part load engine efficiency.
Chavithra Kuruppu, Pesiridis, A, Apostolos Pesiridis, Srithar Rajoo, Rajoo, S, Kuruppu, C   +5 more
core   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Coronary protective effect of the J-Valve during transcatheter aortic valve implantation for patients with aortic stenosis and low coronary artery openings

Journal of Cardiothoracic Surgery
Background In recent years, transcatheter aortic valve implantation (TAVI) has become a widely used treatment for low-risk elderly patients. As an alternative to TAVI via the femoral artery, transapical TAVI (TA-TAVI) is a better surgical choice for ...
Quanhui Xu, Haibo Zhang, Shengxun Wang, Yuehuan Li, Jinglun Shen, Kaisheng Wu, Jiawei Zhou   +6 more
doaj   +1 more source

Long‐Term Outcomes of Patients With Mediastinal Radiation–Associated Severe Aortic Stenosis and Subsequent Surgical Aortic Valve Replacement: A Matched Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Cardiac disease after mediastinal radiotherapy for thoracic malignancy (chest radiotherapy [XRT]) often manifests as progressive aortic stenosis. In patients with XRT‐induced severe aortic stenosis undergoing surgical aortic valve replacement (
Eoin Donnellan, Ahmad Masri, Douglas R. Johnston, Gosta B. Pettersson, L. Leonardo Rodriguez, Zoran B. Popovic, Eric E. Roselli, Nicholas G. Smedira, Lars G. Svensson, Brian P. Griffin, Milind Y. Desai   +10 more
doaj   +1 more source

Reversible Thermo-Responsive Valve for Microfluidic Paper-Based Analytical Devices

Micromachines, 2022
Fluid control on a paper channel is necessary for analysis with multiple reagents, such as enzyme-linked immunosorbent assay (ELISA) in microfluidic paper-based analytical devices (µPADs).
Hiroki Toda, Wataru Iwasaki, Nobutomo Morita, Taisei Motomura, Kenshin Takemura, Masaya Nagano, Yoshitaka Nakanishi, Yuta Nakashima   +7 more
doaj   +1 more source