Results 41 to 50 of about 182,049 (317)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Simulation and optimisation design of the solenoid valve

open access: yesThe Journal of Engineering, 2019
This study first analyses the problems that the solenoid valve generates during operation. Then the electromagnetic valve was modelled and ANSYS finite element analysis simulation software was used to simulate the electromagnetic field and transient ...
Yunhong Zheng   +2 more
doaj   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang   +22 more
wiley   +1 more source

Behaviour of unimorph ring-shaped piezoelectric actuator in fluidic valve

open access: yesThe Journal of Engineering, 2018
This article focuses on the behaviour analysis of an unimorph ring-shaped piezoelectric plate that is used as an actuator in a fluidic valve. First, the system modelling is discussed by using the material mechanical properties of the piezoelectric plate ...
XuDong Wang   +3 more
doaj   +1 more source

Valve-in-Valve Procedure in Failed Transcatheter Aortic Valves

open access: yesJACC: Cardiovascular Imaging, 2019
Transcatheter aortic valve replacement (TAVR) is being increasingly used for the treatment of severe native aortic valve stenosis. Initially performed in patients with prohibitive or high surgical risk, TAVR is now considered as a valid alternative in patients with intermediate risk and is ...
Salaun, Erwan   +10 more
openaire   +2 more sources

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

open access: yesArthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli   +10 more
wiley   +1 more source

Analysis of cavitation flow in conical throttle valve with different cone angle

open access: yesThe Journal of Engineering, 2018
Cavitation is a common phenomenon in industrial control valves, which has a strong influence on the internal flow. Herein, characteristics of cavitation flow inside conical throttle valve have been numerically analysed using a two-phase mixture model via
Jie He, Beibei Li, Xiumei Liu
doaj   +1 more source

Mechanical–electrical–pneumatic systematic design exploration of hexapod robot experimental prototype

open access: yesThe Journal of Engineering, 2019
Aiming at the problem of the detect and rescue in the coal mine with the leaking vas, a type of pneumatic hexapod explored robot which uses a high pressure nitrogen cylinder as the power producer is designed.
Long Bai   +4 more
doaj   +1 more source

A meta‐analysis of valve‐in‐valve and valve‐in‐ring transcatheter mitral valve implantation [PDF]

open access: yesJournal of Interventional Cardiology, 2018
ObjectivesWe performed a meta‐analysis of transcatheter mitral valve implantation (TMVI) for deteriorated bioprosthetic valves (valve‐in‐valve [VIV]‐TMVI) and/or failed annuloplasty rings (valve‐in‐ring [VIR]‐TMVI), comparing observed early (30‐day) mortality with predicted operative mortality.BackgroundIt remains unclear whether VIV/VIR‐TMVI reduces ...
Hisato, Takagi   +3 more
openaire   +2 more sources

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