Results 71 to 80 of about 5,999,607 (293)

VALVULAR HEART DISEASE AND PREGNANCY

, 2023
Valvular heart disease during pregnancy is a high-risk situation for both the parturient and the fetus. Indeed, Cardiovascular changes during pregnancy can decompensate heart disease.
R. Maakoul, F. Benmessaoud, W. Benbrahim and S. Bargach   +2 more
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

The methods of treatment of atrial fibrillation in patients with valvular heart disease [PDF]

, 2019
The article presents literature data on the methods of treatment of atrial fibrillation in patients with valvular heart disease. The clinical efficacy of surgical treatment in patients with atrial fibrillation is presented – surgical isolation of the ...
O.M. Grytsay, V.О. Kuts, B.M. Todurov, I.Y. Mokryk, E.V. Zhytyns’kiy, О.J. Zharinov, Y.V. Skybchyk   +6 more
core   +2 more sources

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Valvular heart disease is changing – a challenge for Africa

, 2015
The pattern of valvular heart disease is changing in Western populations. There are implications for Africa as healthcare improves and people live longer.
David A. Tibbutt, DM, FRCP
core  

Guidelines on the management of valvular heart disease (version 2012)

, 2012
Universitätsklinik für KardiologieUniversitätsklinik für Herz- und Gefässchirurgie46The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery ...
Swedberg, Karl, Pierard, Luc, Zamorano, Jose Luis, Iung, Bernard, Lancellotti, Patrizio, Stepinska, Janina, Alfieri, Ottavio, Barón-Esquivias, Gonzalo, Carrel, Thierry, Vahanian, Alec, Andreotti, Felicita, Evangelista, Arturo, Windecker, Stephan, European Society of Cardiology, ESC, Borger, Michael Andrew, Falk, Volkmar, Takkenberg, Johanna, De Bonis, Michele, Zembala, Marian, Schäfers, Hans-Joachim, Price, Susanna, Baumgartner, Helmut, European Association for Cardio-Thoracic Surgery, EACTS, Schuler, Gerhard, Von Oppell, Ulrich Otto, Antunes, Manuel J   +25 more
core   +1 more source

A case control investigation of the relation between hyperlipidaemia and calcific aortic valve stenosis [PDF]

, 1997
Objective To investigate the relation of hyperlipidaemia to calcific aortic valve stenosis. Design A case-control study designed to detect a clinically relevant difference in the fasting plasma concentrations of total cholesterol between the groups at ...
Stevenson, R N, Lord, John R, Wilmshurst, P T, Griffiths, H   +3 more
core   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Sex differences in publication volume and quality in congenital heart disease: are women disadvantaged?

Open Heart, 2019
Background Women are underrepresented in leading medical positions and academia. The gender-gap in authorship of congenital heart disease (CHD) publications remains unknown.
Michael A Gatzoulis, Gerhard Paul Diller, Aleksander Kempny, Sophie van Doren, Margarita Brida, Sonya V Babu-Narayan, Ulrike M M Bauer, Helmut Baumgartner   +7 more
doaj   +1 more source

Epidemiology of Valvular Heart Disease

, 2022
Acquired diseases of the aortic and mitral valves are the most common cause of morbidity and mortality among Valvular heart diseases. Aortic stenosis (AS) is increasing in incidence in the United States (4,43 US), driven largely by an aging demographic ...
Antevil, Jared L, Duggan, John P, Trachiotis, Gregory D, Peters, Alex S   +3 more
core   +1 more source