Results 31 to 40 of about 108,023 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Positively Charged Macroparticles in Low-Temperature Plasma

East European Journal of Physics, 2022
The evolution of a positively charged metallic macroparticle placed into the low-temperature plasma is considered. The influence of the value of the initial macroparticle charge on the dynamics of the electrical potential and temperature of the ...
Aleksander A. Bizyukov, Aleksandr D. Chibisov, Dmitry V. Chibisov, Oksana A. Zhernovnykova, Tamara I. Deуnichenko, Nikolai N. Yunakov   +5 more
doaj   +1 more source

Vaporizer Position

Veterinary Clinics of North America: Small Animal Practice, 1992
The vaporizers that are positioned outside of the circle have known constant output concentrations and are not affected by positive pressure ventilation. The vaporizers that are positioned inside the circle system have unknown, variable output concentrations and are markedly affected by positive pressure ventilation.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Shock induced vaporization of anhydrite CaSO4 and calcite CaCO3 [PDF]

, 2000
Discovery of abundant anhydrite (CaSO4) and gypsum (CaSO4.2H2O) in the otherwise carbonate sediments comprising the upper portion of the rocks contained within the Chicxulub impact crater has prompted research on the shock-induced vaporization of these ...
Ahrens, Thomas J., Gupta, Satish C., Yang, Wenbo   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Comparative Analysis of a Single Fuel Droplet Evaporation [PDF]

Journal of Chemical and Petroleum Engineering, 2019
In this research, the results of comparative analysis of a single fuel droplet evaporation models are presented. Three well-known evaporation models including Spalding, Borman-Johnson and Abramzon-Sirignano models are analyzed using Computational Fluid ...
Somayeh Jafari, Hasan Khaleghi, Reza Maddahian   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Apparatus to control and visualize the impact of a high-energy laser pulse on a liquid target [PDF]

, 2017
We present an experimental apparatus to control and visualize the response of a liquid target to a laser-induced vaporization. We use a millimeter-sized drop as target and present two liquid-dye solutions that allow a variation of the absorption ...
Alexander L. Klein, de Gennes P.-G., Detlef Lohse, Eason R., Hanneke Gelderblom, Hecht E., Michel Versluis, Settles G. S., Weichel H.   +8 more
core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source