Results 1 to 10 of about 136 (97)

Drug Delivery in Photodynamic Therapy [PDF]

Pharmaceutics, 2023
Photodynamic therapy (PDT) has gained prominence as a non-invasive and selective treatment option for solid tumors and non-oncological diseases [...]
Francesca Moret, Greta Varchi
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SMYD3 Modulates AMPK-mTOR Signaling Balance in Cancer Cell Response to DNA Damage [PDF]

Cells, 2023
Cells respond to DNA damage by activating a complex array of signaling networks, which include the AMPK and mTOR pathways. After DNA double-strand breakage, ATM, a core component of the DNA repair system, activates the AMPK-TSC2 pathway, leading to the ...
Martina Lepore Signorile, Paola Sanese, Elisabetta Di Nicola, Candida Fasano, Giovanna Forte, Katia De Marco, Vittoria Disciglio, Marialaura Latrofa, Antonino Pantaleo, Greta Varchi, Alberto Del Rio, Valentina Grossi, Cristiano Simone   +12 more
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SMYD3 Modulates the HGF/MET Signaling Pathway in Gastric Cancer [PDF]

Cells, 2023
Gastric cancer (GC) is the third most deadly cancer worldwide. Considerable efforts have been made to find targetable drivers in order to improve patient outcomes.
Katia De Marco, Martina Lepore Signorile, Elisabetta Di Nicola, Paola Sanese, Candida Fasano, Giovanna Forte, Vittoria Disciglio, Antonino Pantaleo, Greta Varchi, Alberto Del Rio, Valentina Grossi, Cristiano Simone   +11 more
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Pheophorbide A and Paclitaxel Bioresponsive Nanoparticles as Double-Punch Platform for Cancer Therapy [PDF]

Pharmaceutics, 2021
Cancer therapy is still a challenging issue. To address this, the combination of anticancer drugs with other therapeutic modalities, such as light-triggered therapies, has emerged as a promising approach, primarily when both active ingredients are ...
Francesca Moret, Luca Menilli, Manuele Battan, Daniele Tedesco, Marta Columbaro, Andrea Guerrini, Greta Avancini, Claudia Ferroni, Greta Varchi   +8 more
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Two Beats One: Osteosarcoma Therapy with Light-Activated and Chemo-Releasing Keratin Nanoformulation in a Preclinical Mouse Model [PDF]

Pharmaceutics, 2022
Osteosarcoma treatment is moving towards more effective combination therapies. Nevertheless, these approaches present distinctive challenges that can complicate the clinical translation, such as increased toxicity and multi-drug resistance.
Elisa Martella, Barbara Dozza, Claudia Ferroni, Clement Osuru Obeyok, Andrea Guerrini, Daniele Tedesco, Ilse Manet, Giovanna Sotgiu, Marta Columbaro, Marco Ballestri, Lucia Martini, Milena Fini, Enrico Lucarelli, Greta Varchi, Serena Duchi   +14 more
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Mesenchymal stromal cells mediated delivery of photoactive nanoparticles inhibits osteosarcoma growth in vitro and in a murine in vivo ectopic model [PDF]

Journal of Experimental & Clinical Cancer Research, 2020
Background Osteosarcoma (OS) is an aggressive malignant neoplasm that still suffers from poor prognosis in the case of distal metastases or occurrence of multi-drug resistance.
Stefania Lenna, Chiara Bellotti, Serena Duchi, Elisa Martella, Marta Columbaro, Barbara Dozza, Marco Ballestri, Andrea Guerrini, Giovanna Sotgiu, Tommaso Frisoni, Luca Cevolani, Greta Varchi, Mauro Ferrari, Davide Maria Donati, Enrico Lucarelli   +14 more
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Light-Induced Therapies for Prostate Cancer Treatment [PDF]

Frontiers in Chemistry, 2019
Prostate cancer (PC) is one of the most widespread tumors affecting the urinary system and the fifth-leading cause from cancer death in men worldwide.
Claudia Ferroni, Alberto Del Rio, Alberto Del Rio, Cecilia Martini, Elisabetta Manoni, Greta Varchi   +5 more
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HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy–an in vitro exploration [PDF]

Frontiers in Chemistry
Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer still lacking effective treatment options. Chemotherapy in combination with immunotherapy can restrict tumor progression and repolarize the tumor ...
Matilde Tubertini, Matilde Tubertini, Luca Menilli, Celeste Milani, Cecilia Martini, Maria Luisa Navacchia, Marta Nugnes, Manuela Bartolini, Marina Naldi, Daniele Tedesco, Elisa Martella, Andrea Guerrini, Claudia Ferroni, Francesca Moret, Greta Varchi   +14 more
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Anticancer activity of paclitaxel-loaded keratin nanoparticles in two-dimensional and perfused three-dimensional breast cancer models [PDF]

International Journal of Nanomedicine, 2018
Federica Foglietta,1 Giulio C Spagnoli,2,3 Manuele Giuseppe Muraro,2 Marco Ballestri,4 Andrea Guerrini,4 Claudia Ferroni,4 Annalisa Aluigi,4 Giovanna Sotgiu,4 Greta Varchi4 1Department of Drug Science & Technology, University of Torino, Torino ...
Foglietta F, Spagnoli GC, Muraro MG, Ballestri M, Guerrini A, Ferroni C, Aluigi A, Sotgiu G, Varchi G   +8 more
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Effect of small molecules modulating androgen receptor (SARMs) in human prostate cancer models. [PDF]

PLoS ONE, 2013
The management of hormone-refractory prostate cancer represents a major challenge in the therapy of this tumor, and identification of novel androgen receptor antagonists is needed to render treatment more effective.
Anna Tesei, Carlo Leonetti, Marzia Di Donato, Elisa Gabucci, Manuela Porru, Greta Varchi, Andrea Guerrini, Dino Amadori, Chiara Arienti, Sara Pignatta, Giulia Paganelli, Michele Caraglia, Gabriella Castoria, Wainer Zoli   +13 more
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