Results 11 to 20 of about 12,608 (240)

The Antiviral Activity of Varenicline against Dengue Virus Replication during the Post-Entry Stage

Biomedicines, 2023
Dengue virus (DENV) poses a significant global health challenge, with millions of cases each year. Developing effective antiviral drugs against DENV remains a major hurdle. Varenicline is a medication used to aid smoking cessation, with anti-inflammatory
Ching-Lin Lin, Yan-Tung Kiu, Ju-Ying Kan, Yu-Jen Chang, Ping-Yi Hung, Chih-Hao Lu, Wen-Ling Lin, Yow-Wen Hsieh, Jung-Yie Kao, Nien-Jen Hu, Cheng-Wen Lin   +10 more
doaj   +2 more sources

Varenicline Prevents LPS-Induced Inflammatory Response via Nicotinic Acetylcholine Receptors in RAW 264.7 Macrophages

Frontiers in Molecular Biosciences, 2021
The cholinergic anti-inflammatory pathway plays an important role in controlling inflammation. This study investigated the effects of varenicline, an α7 nicotinic acetylcholine receptor (α7nAChR) agonist, on inflammatory cytokine levels, cell ...
Elif Baris, Elif Baris, Hande Efe, Mukaddes Gumustekin, Mualla Aylin Arici, Metiner Tosun   +5 more
doaj   +2 more sources

Neuropsychiatric safety of varenicline in the general and COPD population with and without psychiatric disorders: a retrospective cohort study in a real-world setting

BMJ Open, 2021
Objectives To evaluate the real-world association between varenicline and neuropsychiatric adverse events (NPAEs) in general and chronic obstructive pulmonary disease (COPD) population with and without psychiatric disorders compared with nicotine ...
Yuanyuan Wang, Bob Wilffert, Eelko Hak, H. Marike Boezen, Jens H. Bos, Catharina C.M. Schuiling-Veninga, Job F. M. van Boven   +6 more
doaj   +2 more sources

Varenicline and counseling for vaping cessation: a double-blind, randomized, parallel-group, placebo-controlled trial

BMC Medicine, 2023
Background Vaping cessation is virtually unexplored. The efficacy and safety of varenicline for vaping cessation has not been studied and rigorous research is required to advance best practice and outcomes for people who use electronic cigarettes (EC ...
Pasquale Caponnetto, Davide Campagna, Jasjit S. Ahluwalia, Christopher Russell, Marilena Maglia, Paolo Marco Riela, Carmelo Fabio Longo, Barbara Busa, Riccardo Polosa   +8 more
doaj   +2 more sources

Two-year efficacy of varenicline tartrate and counselling for inpatient smoking cessation (STOP study): A randomized controlled clinical trial.

PLoS ONE, 2020
IntroductionVarenicline tartrate is superior for smoking cessation to other tobacco cessation therapies by 52 weeks, in the outpatient setting. We aimed to evaluate the long-term (104 week) efficacy following a standard course of inpatient-initiated ...
Kristin V Carson-Chahhoud, Brian J Smith, Matthew J Peters, Malcolm P Brinn, Faisal Ameer, Kuljit Singh, Robert Fitridge, Simon A Koblar, Jim Jannes, Antony J Veale, Sharon Goldsworthy, Khin Hnin, Adrian J Esterman   +12 more
doaj   +2 more sources

Varenicline versus nicotine replacement therapy for long-term smoking cessation: an observational study using the Clinical Practice Research Datalink

Health Technology Assessment, 2020
Background: Smoking is the leading avoidable cause of illness and premature mortality. The first-line treatments for smoking cessation are nicotine replacement therapy and varenicline.
Neil M Davies, Amy E Taylor, Gemma MJ Taylor, Taha Itani, Tim Jones, Richard M Martin, Marcus R Munafò, Frank Windmeijer, Kyla H Thomas   +8 more
doaj   +2 more sources

Association of the Chantix Recall With US Prescribing of Varenicline and Other Medications for Nicotine Dependence.

JAMA Network Open, 2023
This cross-sectional study evaluates the association between the 2021 varenicline tartrate recall and prescribing of varenicline and other medications for nicotine dependence in a large US national patient cohort.
A. E. Lang, U. Patel, Jonathan Fitzpatrick, Tiffany Lee, Margo McFarland, C. Good   +5 more
semanticscholar   +1 more source

Efficacy of Varenicline in the Treatment of Alcohol Dependence: An Updated Meta-Analysis and Meta-Regression

International Journal of Environmental Research and Public Health, 2023
Background: Although varenicline has been used for alcohol dependence (AD) treatment, its efficacy for this condition remains controversial. Aims: This systematic review and meta-analysis of randomized controlled trials (RCTs) assesses the efficacy and ...
Wiraphol Phimarn, Rotjanawat Sakhancord, Peerasaran Paitoon, Kritsanee Saramunee, Bunleu Sungthong   +4 more
semanticscholar   +1 more source

Varenicline Solution Nasal Spray: A Review in Dry Eye Disease

Drugs, 2022
Increasing endogenous tear film production via pharmacological neuroactivation of the nasolacrimal reflex [NLR; also known as the trigeminal parasympathetic pathway (TPP)] is a novel therapeutic approach to treating dry eye disease (DED).
J. Frampton
semanticscholar   +1 more source

Effectiveness of Varenicline and Cytisine for Alcohol Use Reduction Among People With HIV and Substance Use

JAMA Network Open, 2022
This randomized clinical trial compares the effectiveness of varenicline and cytisine with nicotine replacement therapy for reducing alcohol consumption among individuals with HIV who smoke daily and engage in risky drinking.
H. Tindle, M. Freiberg, D. Cheng, N. Gnatienko, E. Blokhina, T. Yaroslavtseva, S. Bendiks, G. Patts, J. Hahn, K. So-Armah, M. Stein, K. Bryant, D. Lioznov, E. Krupitsky, J. Samet   +14 more
semanticscholar   +1 more source