Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats [PDF]
, 2015 Background: Alcohol and nicotine are largely co-abused. Here, we investigated whether concurrent exposure to both addictive drugs influences each other's consumption and whether varenicline attenuates alcohol consumption in the presence of nicotine ...
Ciccocioppo, Roberto +4 more
core +1 more source
Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou +6 more
wiley +1 more source
Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP. [PDF]
, 2015 Cys-loop receptors are the site of action of many therapeutic drugs. One of these is the smoking cessation agent varenicline, which has its major therapeutic effects at nicotinic acetylcholine (nACh) receptors but also acts at 5-HT3 receptors.
Lillestol, Reidun K +3 more
core +3 more sources
Addiction, Volume 120, Issue 4, Page 770-778, April 2025.Abstract Aims To determine patterns of e‐cigarette flavour use (sweet, tobacco, menthol/mint) in interventional studies of e‐cigarettes for stopping smoking, and to estimate associations between flavours and smoking/vaping outcomes. Methods Update of secondary data analyses, including meta‐analyses subgrouped by flavour provision and narrative ...
Nicola Lindson +9 more
wiley +1 more source
A genome-wide association study of nausea incidence in varenicline-treated cigarette smokers.
Nicotine & Tobacco Research, 2021 INTRODUCTION Varenicline is the most efficacious smoking cessation treatment, however long-term cessation rates tend to be
Meghan J. Chenoweth +3 more
semanticscholar +1 more source
The Economic Impact of Smoking and of Reducing Smoking Prevalence: Review of Evidence [PDF]
BACKGROUND: Tobacco smoking is the cause of many preventable diseases and premature deaths in the UK and around the world. It poses enormous health- and non-health-related costs to the affected individuals, employers, and the society at large.
Brown, AK, Ekpu, VU
core +1 more source
Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review
Addiction, EarlyView.Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper +7 more
wiley +1 more source
Looking Back and Going Forward: Roles of Varenicline and Electronic Cigarettes in Smoking Cessation
Cureus, 2021 Tobacco use is the single largest preventable cause of death in the United States (US). The national goal of reducing the prevalence of adult cigarette smoking to 12% was retained for 20 years due to non-attainment.
Ebenezer O. Oloyede +3 more
semanticscholar +1 more source
Varenicline for smoking cessation and reduction in people with severe mental illnesses : systematic review and meta-analysis [PDF]
, 2016 AIMS: To determine the effectiveness and safety of varenicline in treating tobacco dependence in patients with severe mental illness. DESIGN: A systematic review and meta-analysis of randomised controlled trials that compared varenicline with a placebo ...
Brabyn, Sally +4 more
core +1 more source
Addiction, EarlyView.Abstract Background and Aims The subjective experience of drug craving is characterized by an overwhelming urge to consume substances. Due to strong validity and ease of use, self‐report measures are widely employed to assess substance‐related motivational dynamics.
Matin Toulami +9 more
wiley +1 more source