Results 91 to 100 of about 3,116,070 (323)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

ClustOfVar: An R Package for the Clustering of Variables [PDF]

Journal of Statistical Software (2012), 50(13), 1-16, 2011
Clustering of variables is as a way to arrange variables into homogeneous clusters, i.e., groups of variables which are strongly related to each other and thus bring the same information. These approaches can then be useful for dimension reduction and variable selection.
arxiv  

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

All-relevant feature selection using multidimensional filters with exhaustive search [PDF]

arXiv, 2017
This paper describes a method for identification of the informative variables in the information system with discrete decision variables. It is targeted specifically towards discovery of the variables that are non-informative when considered alone, but are informative when the synergistic interactions between multiple variables are considered.
arxiv  

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Interactions Between Leaf Area Dynamics and Vineyard Performance, Environment, and Viticultural Practices

Agriculture
The Leaf Area Index (LAI) is a key physiological metric in viticulture, associated with vine health, yield, and responsiveness to environmental and management factors.
Yishai Netzer, Noa Ohana-Levi
doaj   +1 more source

Variable Importance Clouds: A Way to Explore Variable Importance for the Set of Good Models [PDF]

arXiv, 2019
Variable importance is central to scientific studies, including the social sciences and causal inference, healthcare, and other domains. However, current notions of variable importance are often tied to a specific predictive model. This is problematic: what if there were multiple well-performing predictive models, and a specific variable is important ...
arxiv  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Solar-Enhanced Photocatalytic Decontamination of Water from Tetracycline Antibiotics and Its Application in Aquaculture

Proceedings
The occurrence of emerging pharmaceutical contaminants, especially antibiotics in water systems is an alarming issue and is addressed using Advanced Oxidation Processes (AOPs). In this study, the degradation of antibiotic tetracycline hydrochloride (TCT)
Padinchare Veettil Gayathri, Divya Nair, Shijo Joseph   +2 more
doaj   +1 more source

Understanding the atmospheric circulations that lead to high particulate matter concentrations on the west coast of Namibia

Clean Air Journal, 2017
Atmospheric circulations play a significant role in determining the extent and impact of local and regional air pollution. The Erongo Region, located in the western part of Namibia, falls within the west coast arid zone of southern Africa, and is ...
H Liebenberg-Enslin, H Rauntenbach, R von Gruenewaldt, L Burger   +3 more
doaj   +1 more source