Results 111 to 120 of about 5,040,318 (301)

Addition of 24‐Hour Heart Rate Variability Parameters to the Cardiovascular Health Study Stroke Risk Score and Prediction of Incident Stroke: The Cardiovascular Health Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundHeart rate variability (HRV) characterizes cardiac autonomic functioning. The association of HRV with stroke is uncertain. We examined whether 24‐hour HRV added predictive value to the Cardiovascular Health Study clinical stroke risk score (CHS‐
Rohan K. Bodapati, Jorge R. Kizer, Willem J. Kop, Hooman Kamel, Phyllis K. Stein   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Viruses Previously Classified as CRF146_BC, a Circulating Recombinant Form of HIV-1 Recently Reported in Brazil, Represent Different Recombinant Forms, One of Which Is Circulating in Spain

Viruses
Circulating recombinant forms (CRFs) are important components of the HIV-1 pandemic. Previous studies have reported the propagation of diverse HIV-1 CRFs of South American origin in Europe.
Ana Donoso, María Moreno-Lorenzo, Elena Delgado, Javier E. Cañada-García, José Antonio Iribarren, Yolanda Salicio, Sonia Benito, Clara Lorente-Sorolla, Jorge Del Romero-Guerrero, María Begoña Baza-Caraciolo, Francisco Díez-Fuertes, Pilar Zamarrón, Raquel Téllez, Ana Miqueleiz, Carmen Gómez-González, Sandra Cortizo, Luis Morano, Michael M. Thomson   +17 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Variables [PDF]

Revista de la Facultad de Ciencias Médicas de Córdoba, 2009
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optimizing a Bayesian Method for Estimating the Hurst Exponent in Behavioral Sciences

Axioms
The Bayesian Hurst–Kolmogorov (HK) method estimates the Hurst exponent of a time series more accurately than the age-old Detrended Fluctuation Analysis (DFA), especially when the time series is short.
Madhur Mangalam, Taylor J. Wilson, Joel H. Sommerfeld, Aaron D. Likens   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Desaceleraciones variables [Variable decelerations]

Revista de la Federación Centroamericana de Obstetricia y Ginecología, 2020
<p>Paciente femenina de 22 años con gestación de 38 semanas. Acude con historia de salida espontánea de líquido transvaginal en su casa, asociado a contracciones uterinas de 6 horas de evolución. Al llegar al hospital, con 3 centímetros de dilatación, 80% de borramiento, cefálico, membranas ovulares rotas, líquido meconial.
openaire   +2 more sources