Results 121 to 130 of about 5,040,318 (301)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Prevalence of Self-Medicated Use of Antibiotics among the Population in Ernakulam District in Kerala, India

Medical Sciences Forum
Self-medication (SM) of antibiotics has become a prevalent reason for the development of antibiotic resistance. This study aims to assess the use of self-medication practices with antibiotics and related factors among the population of Ernakulam district,
Divya Nair, Padinchare Veettil Gayathri, Girish Gopinath   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Author Correction: Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America

Scientific Reports, 2021
Elena Delgado, Aurora Fernández-García, Marcos Pérez-Losada, María Moreno-Lorenzo, Ismael Fernández-Miranda, Sonia Benito, Vanessa Montero, Horacio Gil, Silvia Hernáez, Josefa Muñoz, Miren Z. Zubero-Sulibarria, Elena García-Bodas, Mónica Sánchez, Jorge del Romero, Carmen Rodríguez, Luis Elorduy, Elena Bereciartua, Esther Culebras, Icíar Rodríguez-Avial, María Luisa Giménez-Alarcón, Carmen Martín-Salas, Carmen Gómez-González, José J. García-Irure, Gema Cenzual, Ana Martínez-Sapiña, María Maiques-Camarero, Lucía Pérez-Álvarez, Michael M. Thomson   +27 more
doaj   +1 more source

Long-Term Global Trends in Vineyard Coverage and Fresh Grape Production

Agriculture
Monitoring and tracking the long-term dynamics of vineyard coverage and fresh grape production can support sustainable agricultural planning under evolving climate, market, and land-use pressures. This study presents a comprehensive, data-driven analysis
Noa Ohana-Levi, Yishai Netzer
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Interactions Between Leaf Area Dynamics and Vineyard Performance, Environment, and Viticultural Practices

Agriculture
The Leaf Area Index (LAI) is a key physiological metric in viticulture, associated with vine health, yield, and responsiveness to environmental and management factors.
Yishai Netzer, Noa Ohana-Levi
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

EMG-Based Simulation for Optimization of Human-in-the-Loop Control in Simple Robotic Walking Assistance

Journal of Sensor and Actuator Networks
Exoskeletons offer promising solutions for enhancing human mobility; however, personalizing assistance parameters to optimize physiological outcomes remains challenging.
Arash Mohammadzadeh Gonabadi, Nathaniel H. Hunt, Farahnaz Fallahtafti   +2 more
doaj   +1 more source