Results 141 to 150 of about 2,766,945 (316)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
EntropyVarious fields within biological and psychological inquiry recognize the significance of exploring long-range temporal correlations to study phenomena.
Madhur Mangalam, Aaron D. Likens
doaj +1 more source
Novel spectral-timing methods for X-ray binary variability studies
, 2012 This work explores the connection between the spectral properties of the X-ray emission produced by black hole X-ray binaries (BHXRBs) and the variability properties of these sources that are embedded in light curves.
Cassatella, Pablo M +1 more
core
Can we identify non-stationary dynamics of trial-to-trial variability?"
, 2014 Identifying sources of the apparent variability in non-stationary scenarios is a fundamental problem in many biological data analysis settings. For instance, neurophysiological responses to the same task often vary from each repetition of the same ...
Alejandro Tabas-Diaz +11 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
ProceedingsThe occurrence of emerging pharmaceutical contaminants, especially antibiotics in water systems is an alarming issue and is addressed using Advanced Oxidation Processes (AOPs). In this study, the degradation of antibiotic tetracycline hydrochloride (TCT)
Padinchare Veettil Gayathri +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Evolving EarthThe study examines two contrasting settings in Kochi, Kerala, comprising urban and peri-urban clusters that experience different levels of anthropogenic pressure. Surface soil samples were analysed for trace metals to quantify concentrations, map spatial
A.R. Sabitha +5 more
doaj +1 more source
, 2007 Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60–64 years.
Wen, W +5 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source