Results 151 to 160 of about 2,766,945 (316)

Variables of Usability [PDF]

, 2013
Though many have proposed heuristics, maximums, and guidelines to describe the various aspects of heuristic usability analysis, none offer a comprehensive variable set that is both valid and reliable. This paper proposes an eight-variable criteria-set through which usability inspections can be performed.
openaire   +1 more source

Exchange rate variability, market activity and heterogeneity [PDF]

We study the role played by geographic and bank-size heterogeneity in the relation between exchange rate variability and market activity. We find some support for the hypothesis that increases in short-term global interbank market activity, which can be ...
Dagfinn Rime, Genaro Sucarrat
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Assessment of liquefaction susceptibility using machine learning technique in the inner wedge of Indo-Burmese range

Discover Geoscience
The synclinal valleys in the outer wedge of the Indo-Burmese Ranges (IBR), part of zipper tectonics, are more prone to earthquake-induced liquefaction due to thick unconsolidated, immature sediments with shallow groundwater conditions. The present study,
Drishya Girishbai, Arun Bhadran, A. L. Achu, Girish Gopinath, B. P. Duarah   +4 more
doaj   +1 more source

Interannual variability of tropospheric composition : the influence of changes in emissions, meteorology and clouds [PDF]

, 2010
We have run a chemistry transport model (CTM) to systematically examine the drivers of interannual variability of tropospheric composition during 1996-2000.
P. Braesicke, N. H. Savage, Braesicke, P., Wild, O., Pyle, J. A., Savage, N. H., J. A. Pyle, A. Voulgarakis, Young, Paul, Voulgarakis, A., G. D. Carver, O. Wild, Carver, G. D., P. J. Young   +13 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The use of symmetry for models with variable-size variables

Mathematical Social Sciences
This paper presents a universal representation of symmetric (permutation-invariant) functions with multidimensional variable-size variables. These representations help justify approximation methods that aggregate information from each variable using moments.
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Spatial variability of groundwater recharge - I. Is it really variable?

, 2004
The spatial variability of recharge is an important consideration in estimating recharge especially as all methods of estimating it are 'point' estimates and in most places recharge varies in space.
De Silva, RP
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