Results 111 to 120 of about 1,946,034 (299)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Dynamic deep learning based super-resolution for the shallow water equations
Machine Learning: Science and TechnologyCorrectly capturing the transition to turbulence in a barotropic instability requires fine spatial resolution. To reduce computational cost, we propose a dynamic super-resolution approach where a transient simulation on a coarse mesh is frequently ...
Maximilian Witte +6 more
doaj +1 more source
An Approximate Relation between the Variability of Wind and the Variability of Pressure or Height in the Atmosphere [PDF]
, 1957 C. Eugene Buell
openalex +1 more source
Mathematics and Variables ─ Independent Variables and Dependent Variables
Kagaku tetsugaku, 2021 openaire +3 more sources
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
I. Variability, Symmetry and Fertility In an abnormal Speoies [PDF]
, 1902 C. B. Davenport
openalex +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Modeling Dual-Task Performance: Identifying Key Predictors Using Artificial Neural Networks
BiomimeticsDual-task paradigms that combine cognitive and motor tasks offer a valuable lens for detecting subtle impairments in cognitive and physical functioning, especially in older adults.
Arash Mohammadzadeh Gonabadi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Applied SciencesThis study aimed to evaluate how wearable hip exoskeleton assistance affects phase-dependent gait stability in healthy adults using a novel visualization technique known as gait tube analysis. Hip exoskeletons offer significant potential to enhance human
Arash Mohammadzadeh Gonabadi +1 more
doaj +1 more source