Results 61 to 70 of about 927,137 (277)

Amplitude Modulation of Short Timescale Variability

, 2021
Variability of Classical T Tauri Systems occurs over a range of timescales. A common source of this variability is caused by accretion shocks, which can hamper the detectability of young planets within these systems, further motivating the characterization of accretion signatures. We present analysis of small-amplitude photometric variability in the K2
Biddle, Lauren, Llama, Joe, Cameron, Andrew, Prato, Lisa, Jardine, Moira, Johns-Krull, Chris   +5 more
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Durability assessment of automotive structures under random variable amplitude loading

Advances in Mechanical Engineering, 2018
Durability assessment is essential for assuring the reliability and safety of automotive structures, which subjects to complex random variable amplitude loadings.
Li-Hui Zhao, Hong-Chang Cai, Tong Wang, Song-Lin Zheng   +3 more
doaj   +1 more source

Fatigue crack propagation characteristics of rubbery materials under variable amplitude loading

Results in Physics, 2018
Fatigue failure is a critical issue frequently encountered by the rubber components in service. In this work fatigue crack propagation experiments with an edge-notched pure shear specimen under variable amplitude loading, which brings effectiveness in ...
Xiao-Li Wang, Mei-Ying Liao, You Xu, Xiao-Ang Liu   +3 more
doaj   +1 more source

Waveform simulator Patent [PDF]

, 1971
Sign wave generation simulator for variable amplitude, frequency, damping, and phase pulses for oscilloscope ...
Malmberg, J. H., Moore, C. D.
core   +1 more source

Strip yield modelling of fatigue crack under variable amplitude loading [PDF]

, 2011
The results from 'strip yield' approach of the FASTRAN type models of plasticity induced crack closure effects of fatigue cracks subjected to variable amplitude loadings are presented. The strip yield results are compared with authors' finite element (FE)
Sinclair, Ian, Singh, Konjengbam Darunkumar, Xu, Yigeng   +2 more
core   +1 more source

Separate Universes Do Not Constrain Primordial Black Hole Formation

, 2011
Carr and Hawking showed that the proper size of a spherical overdense region surrounded by a flat FRW universe cannot be arbitrarily large as otherwise the region would close up on itself and become a separate universe.
B. J. Carr, C. W. Misner, D. K. Nadezhin, H. Bondi, I. B. Zel’dovich, J. D. Barrow, J. E. McClintock, Jochen Weller, M. Visser, Michael Kopp, S. Alexander, S. Hawking, S. G. Rubin, S. W. Hawking, Stefan Hofmann, V. Mukhanov, Y. B. Zel’Dovich   +16 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Evidence of New Magnetic Transitions in Late-Type Dwarfs from Gaia DR2 [PDF]

, 2019
The second Gaia data release contains the identification of 147 535 low-mass ($\le 1.4 M_{\odot}$) rotational modulation variable candidates on (or close to) the main sequence, together with their rotation period and modulation amplitude.
Barnes, Sydney A., Distefano, Elisa, Lanzafame, Alessandro C., Spada, Federico   +3 more
core   +2 more sources