Results 31 to 40 of about 153,319 (185)

Of hummingbirds and helicopters: Hovering costs, competitive ability, and foraging strategies [PDF]

, 2004
Wing morphology and flight kinematics profoundly influence foraging costs and the overall behavioral ecology of hummingbirds. By analogy with helicopters, previous energetic studies have applied the momentum theory of aircraft propellers to estimate ...
Altshuler, Douglas L., Dudley, Robert, Stiles, F. Gary   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Fatigue life prediction of z-fibre pinned composite laminate under mode I loading [PDF]

, 2019
A hybrid method is presented combining linear elastic fracture mechanics with nonlinear damage mechanics that can predict the fatigue crack growth rate in z-fibre pinned composites under mode I loading.
Ayre, David, Lemanski, Stuart, Tang, Suchao, Zhang, Xiang   +3 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Very High Cycle Fatigue Damage of TC21 Titanium Alloy under High/Low Two-Step Stress Loading

Crystals, 2023
Very high cycle fatigue (VHCF) tests were carried out under variable amplitude loading for TC21 titanium alloy. The first level of high amplitude loading was set as 950 MPa close to yield strength, and the second level of low amplitude loading was ...
Baohua Nie, Shuai Liu, Yue Wu, Yu Song, Haiying Qi, Binqing Shi, Zihua Zhao, Dongchu Chen   +7 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Study on Multiaxial Fatigue Damage Behavior of HRB335 Under Variable-Amplitude and Variable-Path Loading

Buildings
Fatigue failure is a prevalent concern within structural engineering, often resulting in critical safety risks. The inherent complexity of construction projects leads to structural components experiencing loads of varying amplitudes and diverse load ...
Shihong Huang, Shenghuan Qin, Chengye Liang   +2 more
doaj   +1 more source

Influence of mechanical properties on load sequence effect and fatigue life of aluminium alloy

Journal of Mechanical Engineering and Sciences, 2017
Most of the structural components in real applications are subjected to variable amplitude loading. The load sequence may have a significant effect on the number of cycles to failure. However, the relationship between the mechanical behaviour of material
K.A. Zakaria, F.H.A. Suhadak, M.B. Ali, S. Abdullah, M.J. Ghazali   +4 more
doaj   +1 more source

Residual Stress Relaxation of DRWDs in OSDs under Constant/Variable Amplitude Cyclic Loading

Applied Sciences, 2020
An orthotropic steel deck (OSD) has a complicated structure, and its fatigue life is mainly determined by various welding details. Fatigue assessment of deck-to-rib welding details (DRWDs) under long-term train loads is an important concern for engineers.
Wen Zhong, Youliang Ding, Yongsheng Song, Fangfang Geng, Zhiwen Wang   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source