Results 21 to 30 of about 31,144 (250)

A statistically self-consistent fatigue damage accumulation model including load sequence effects under spectrum loading [PDF]

Fracture and Structural Integrity, 2016
A probabilistic methodology is proposed to evaluate fatigue damage accumulation and fatigue lives of specimens under variable amplitude loading. With probabilistic modifications in the present model, the calculative consistency is achieved between ...
Chen Xianmin, Sun Qin, Dui Hongna, Fan Junling   +3 more
doaj   +2 more sources

Durability assessment of automotive structures under random variable amplitude loading

Advances in Mechanical Engineering, 2018
Durability assessment is essential for assuring the reliability and safety of automotive structures, which subjects to complex random variable amplitude loadings.
Li-Hui Zhao, Hong-Chang Cai, Tong Wang, Song-Lin Zheng   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Study on Multiaxial Fatigue Damage Behavior of HRB335 Under Variable-Amplitude and Variable-Path Loading

Buildings
Fatigue failure is a prevalent concern within structural engineering, often resulting in critical safety risks. The inherent complexity of construction projects leads to structural components experiencing loads of varying amplitudes and diverse load ...
Shihong Huang, Shenghuan Qin, Chengye Liang   +2 more
doaj   +1 more source

Fatigue crack propagation characteristics of rubbery materials under variable amplitude loading

Results in Physics, 2018
Fatigue failure is a critical issue frequently encountered by the rubber components in service. In this work fatigue crack propagation experiments with an edge-notched pure shear specimen under variable amplitude loading, which brings effectiveness in ...
Xiao-Li Wang, Mei-Ying Liao, You Xu, Xiao-Ang Liu   +3 more
doaj   +1 more source

Residual Stress Relaxation of DRWDs in OSDs under Constant/Variable Amplitude Cyclic Loading

Applied Sciences, 2020
An orthotropic steel deck (OSD) has a complicated structure, and its fatigue life is mainly determined by various welding details. Fatigue assessment of deck-to-rib welding details (DRWDs) under long-term train loads is an important concern for engineers.
Wen Zhong, Youliang Ding, Yongsheng Song, Fangfang Geng, Zhiwen Wang   +4 more
doaj   +1 more source

Very High Cycle Fatigue Damage of TC21 Titanium Alloy under High/Low Two-Step Stress Loading

Crystals, 2023
Very high cycle fatigue (VHCF) tests were carried out under variable amplitude loading for TC21 titanium alloy. The first level of high amplitude loading was set as 950 MPa close to yield strength, and the second level of low amplitude loading was ...
Baohua Nie, Shuai Liu, Yue Wu, Yu Song, Haiying Qi, Binqing Shi, Zihua Zhao, Dongchu Chen   +7 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source