Results 101 to 110 of about 5,632,634 (320)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Blow-up phenomena for a pseudo-parabolic system with variable exponents

Electronic Journal of Qualitative Theory of Differential Equations, 2017
In this paper, we consider a pseudo-parabolic system with nonlinearities of variable exponent type \begin{align*} \begin{cases} u_t-\Delta u_t-\operatorname{div}(|\nabla u|^{m(x)-2}\nabla u)=|uv|^{p(x)-2}uv^2 & \mbox{in}\ \Omega\times(0,T),\\
Qi Qi, Yujuan Chen, Qingshan Wang
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Nonlinear elliptic systems with variable exponents and measure data

Moroccan Journal of Pure and Applied Analysis, 2015
In this paper we prove existence results for distributional solutions of nonlinear elliptic systems with a measure data. The functional setting involves Lebesgue-Sobolev spaces as well as weak Lebesgue (Marcinkiewicz) spaces with variable exponents W01,p(
Bendahmane Mostafa, Mokhtari Fares
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

On Variable Exponent Amalgam Spaces

Analele Universitatii "Ovidius" Constanta - Seria Matematica, 2012
Abstract We derive some of the basic properties of weighted variable exponent Lebesgue spaces Lp(.)w (ℝn) and investigate embeddings of these spaces under some conditions. Also a new family of Wiener amalgam spaces W(Lp(.)w ;Lqv) is defined, where the local component is a weighted variable exponent Lebesgue space Lp(.)w (ℝn) and the global component is
openaire   +4 more sources

Multiplicity of weak solutions to degenerate weighted quasilinear elliptic equations with nonlocal terms and variable exponents

Electronic Journal of Qualitative Theory of Differential Equations
This paper studies the existence and multiplicity of weak solutions to degenerate weighted quasilinear elliptic equations with nonlocal nonlinearities and variable exponents.
Khaled Kefi
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Existence of solutions for some nonlinear elliptic unilateral problems with measure data

Electronic Journal of Qualitative Theory of Differential Equations, 2013
In this paper we prove the existence of entropy solution to unilateral problems associated to the equations of the type: $Au-div(\phi(u))=\mu\in L^{1}(\Omega)+W^{-1,p'(x)}(\Omega)$, where $A$ is a Leray-Lions operator acted from $W_{0}^{1,p(x)}(\Omega ...
Chihab Yazough, El houssine Azroul, Hicham Redwane   +2 more
doaj   +1 more source