Results 51 to 60 of about 139,960 (305)

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Low temperature series expansions for the square lattice Ising model with spin S > 1

, 1996
We derive low-temperature series (in the variable $u = \exp[-\beta J/S^2]$) for the spontaneous magnetisation, susceptibility and specific heat of the spin-$S$ Ising model on the square lattice for $S=\frac32$, 2, $\frac52$, and 3.
A J Guttmann, Enting I G, Enting I G, Fox P F, Guttmann A J, I G Enting, I Jensen, Jensen I, Matveev V, Matveev V, Nickel B G, Rushbrooke G S, Sykes M F   +12 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Geometry, Scaling and Universality in the Mass Distributions in Heavy Ion Collisions

, 1993
Various features of the mass yields in heavy ion collisions are studied. The mass yields are discussed in terms of iterative one dimensional discrete maps.
A. Bialas, A. Bialas, A. Z. Mekjian, A.R. DeAngelis, A.Z. Mekjian, A.Z. Mekjian, A.Z. Mekjian, A.Z. Mekjian, B.B. Mandelbrot, C.J. Waddington, D.H.E. Gross, D.H.E. Gross, F.C. Hoppensteadt, J.E. Cohen, M. Ploszajczak, R. Devaney, S. J. Lee, S.J. Lee, S.J. Lee, S.J. Lee, U. Frisch, W.J. Ewens, X. Campi   +22 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Blowup solutions and their blowup rates for parabolic equations with non-standard growth conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2011
This paper concerns classical solutions for homogeneous Dirichlet problem of parabolic equations coupled via exponential sources involving variable exponents. We first establish blowup criteria for positive solutions.
Bingchen Liu, Fengjie Li
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Second-order boundary-value problems with variable exponents

Electronic Journal of Differential Equations, 2014
In this article, we study ordinary differential equations with p(x)-Laplacian and subject to small perturbations of nonhomogeneous Neumann conditions.
Giuseppina D'Agui
doaj