Results 61 to 70 of about 10,058 (262)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Second-order boundary-value problems with variable exponents

Electronic Journal of Differential Equations, 2014
In this article, we study ordinary differential equations with p(x)-Laplacian and subject to small perturbations of nonhomogeneous Neumann conditions.
Giuseppina D'Agui
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Homogeneous Herz spaces with variable exponents and regularity results

Electronic Journal of Qualitative Theory of Differential Equations, 2018
In this paper we deal with the second order divergence form operators $\mathcal{L}$ with coefficients satisfying the vanishing mean oscillation property and we prove some regularity results for a solution to $\mathcal{L}u=\mathrm{div}\, f$, where $f ...
Andrea Scapellato
doaj   +1 more source

Multiplicity of solutions for an anisotropic variable exponent problem

Boundary Value Problems, 2022
In this manuscript an existence result for an anisotropic variable problem which is related to several applications is proved. By considering suitable hypotheses, the multiplicity of solutions is obtained.
Leandro S. Tavares
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Perturbed subcritical Dirichlet problems with variable exponents

Electronic Journal of Differential Equations, 2016
We study a class of nonhomogeneous elliptic problems with Dirichlet boundary condition and involving the p(x)-Laplace operator and power-type nonlinear terms with variable exponent.
Ramzi Alsaedi
doaj  

Sobolev embeddings with variable exponent [PDF]

Studia Mathematica, 2000
Let \(\Omega\) be a bounded open subset of \(\mathbb R^n\) with Lipschitz boundary and let \(p:\overline{\Omega}\to [1,\infty)\) be Lipschitz-continuous. The authors consider the generalised Lebesgue space \(L^{p(x)}(\Omega)\) and the corresponding Sobolev space \(W^{1,p(x)}(\Omega)\), consisting of all \(f\in L^{p(x)}(\Omega)\) with first-order ...
Edmunds, David E., Rákosník, Jiří
openaire   +2 more sources