Results 61 to 70 of about 135,875 (309)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Low temperature series expansions for the square lattice Ising model with spin S > 1

, 1996
We derive low-temperature series (in the variable $u = \exp[-\beta J/S^2]$) for the spontaneous magnetisation, susceptibility and specific heat of the spin-$S$ Ising model on the square lattice for $S=\frac32$, 2, $\frac52$, and 3.
A J Guttmann, Enting I G, Enting I G, Fox P F, Guttmann A J, I G Enting, I Jensen, Jensen I, Matveev V, Matveev V, Nickel B G, Rushbrooke G S, Sykes M F   +12 more
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Small perturbations of critical nonlocal equations with variable exponents

Demonstratio Mathematica, 2023
In this article, we are concerned with the following critical nonlocal equation with variable exponents: (−Δ)p(x,y)su=λf(x,u)+∣u∣q(x)−2uinΩ,u=0inRN\Ω,\left\{\begin{array}{ll}{\left(-\Delta )}_{p\left(x,y)}^{s}u=\lambda f\left(x,u)+{| u| }^{q\left(x)-2}u&
Tao Lulu, He Rui, Liang Sihua
doaj   +1 more source

Geometry, Scaling and Universality in the Mass Distributions in Heavy Ion Collisions

, 1993
Various features of the mass yields in heavy ion collisions are studied. The mass yields are discussed in terms of iterative one dimensional discrete maps.
A. Bialas, A. Bialas, A. Z. Mekjian, A.R. DeAngelis, A.Z. Mekjian, A.Z. Mekjian, A.Z. Mekjian, A.Z. Mekjian, B.B. Mandelbrot, C.J. Waddington, D.H.E. Gross, D.H.E. Gross, F.C. Hoppensteadt, J.E. Cohen, M. Ploszajczak, R. Devaney, S. J. Lee, S.J. Lee, S.J. Lee, S.J. Lee, U. Frisch, W.J. Ewens, X. Campi   +22 more
core   +1 more source

On Variable Exponent Amalgam Spaces

Analele Universitatii "Ovidius" Constanta - Seria Matematica, 2012
Abstract We derive some of the basic properties of weighted variable exponent Lebesgue spaces Lp(.)w (ℝn) and investigate embeddings of these spaces under some conditions. Also a new family of Wiener amalgam spaces W(Lp(.)w ;Lqv) is defined, where the local component is a weighted variable exponent Lebesgue space Lp(.)w (ℝn) and the global component is
openaire   +3 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Blowup solutions and their blowup rates for parabolic equations with non-standard growth conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2011
This paper concerns classical solutions for homogeneous Dirichlet problem of parabolic equations coupled via exponential sources involving variable exponents. We first establish blowup criteria for positive solutions.
Bingchen Liu, Fengjie Li
doaj   +1 more source

Molecular Characterizations and Dualities of Variable Exponent Hardy Spaces Associated with Operators

, 2015
Let $L$ be a linear operator on $L^2(\mathbb R^n)$ generating an analytic semigroup $\{e^{-tL}\}_{t\ge0}$ with kernels having pointwise upper bounds and $p(\cdot):\ \mathbb R^n\to(0,1]$ be a variable exponent function satisfying the globally log-H\"older
Yang, Dachun, Zhuo, Ciqiang
core   +1 more source