Results 101 to 110 of about 1,393,828 (262)

A Study on the Nonlinear Relationship Between the Microenvironment of Cold-Region Tunnels and Workers’ Unsafe Behaviors

Buildings
As a typical enclosed engineering microenvironment, tunnel construction sites exert a profound influence on workers’ unsafe behaviors. This impact is particularly significant in cold regions, where extreme environmental conditions are more likely to ...
Sheng Zhang, Hao Sun, Youyou Jiang, Xingxin Nie, Mingdong Kuang, Zheng Liu   +5 more
doaj   +1 more source

Optimization of Smoking Classification by Applying Neural Network with Variable Importance Using Cytokine Biomarkers. [PDF]

Proc (Int Conf Comput Sci Comput Intell), 2023
Saharan SS, Nagar P, Creasy KT, Stock EO, Feng J, Malloy MJ, Kane JP.   +6 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Thresholding Gini variable importance with a single-trained random forest: An empirical Bayes approach. [PDF]

Comput Struct Biotechnol J, 2023
Dunne R, Reguant R, Ramarao-Milne P, Szul P, Sng LMF, Lundberg M, Twine NA, Bauer DC, Bauer DC.   +8 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Exploring the variable importance in random forests under correlations: a general concept applied to donor organ quality in post-transplant survival. [PDF]

BMC Med Res Methodol, 2023
Wies C, Miltenberger R, Grieser G, Jahn-Eimermacher A.   +3 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Shapley variable importance cloud for interpretable machine learning. [PDF]

Patterns (N Y), 2022
Ning Y, Ong MEH, Chakraborty B, Goldstein BA, Ting DSW, Vaughan R, Liu N.   +6 more
europepmc   +1 more source