Results 171 to 180 of about 16,649 (216)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

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Variable importance analysis: A comprehensive review

Reliability Engineering and System Safety, 2015
Abstract Measuring variable importance for computational models or measured data is an important task in many applications. It has drawn our attention that the variable importance analysis (VIA) techniques were developed independently in many disciplines.
Pengfei Wei, Zhenzhou Lu, Jingwen Song   +2 more
exaly   +2 more sources

The relative importance of import decision variables

Journal of the Academy of Marketing Science, 1983
This is an empirically examined study which explores the purchasing behavior of U.S. import managers by identifying and measuring the use of import decision variables. The study finding supports for the hypothesized relationships between the import decision variables managers use and the countries from which they import.
openaire   +1 more source

A Guide to Important Variables in PBL

Journal of Dental Education, 2008
Dear Dr. Alvares: My colleagues and I wish to bring to the attention of your readers “A Whole System Approach to Problem-Based Learning in Dental, Medical, and Veterinary Sciences: A Guide to Important Variables,” available at [www.manchester.ac.uk/ceebl/resources/resourcepacks/
openaire   +2 more sources

TIME—AN IMPORTANT VARIABLE IN NORMAL DELIVERY

BJOG: An International Journal of Obstetrics & Gynaecology, 1973
SummaryA controlled study showed that speeding birth increased umbilical artery and vein blood pH, most probably by reducing fetal asphyxia. The methods used to speed delivery were simple and were readily applied to a predominantly migrant population. The umbilical artery blood p H in the fast group was significantly higher than in six of seven studies
C, Wood, K H, Ng, D, Hounslow, H, Benning   +3 more
openaire   +2 more sources

Effects of the EEC's Variable Import Levies

Journal of Political Economy, 1980
The mechanics of variable import levies, as used by the EEC for agricultural products, are analyzed. Attention is paid to their destabilizing effects on world markets and to the way in which they can capture not only economic rent associated with trade restrictions but also the subsidy payments of exporting countries.
Sampson, Gary P, Snape, Richard H
openaire   +1 more source

Variables importance in questionnaire data on advertising

Expert Systems with Applications, 2011
Abstract In this article, we deal with the problem of measuring the importance of features, that determine the purchase of the product after being exposed to an advertisement. We use an algorithm called Monte Carlo feature selection, which is based on multiple usage of decision trees, to achieve a ranking of variables from the questionnaire data. Our
Aniceta Cymbala, Marcin Owczarczuk
openaire   +1 more source