Results 181 to 190 of about 4,433,966 (292)

Assessing variable importance in survival analysis using machine learning. [PDF]

Biometrika
Wolock CJ, Gilbert PB, Simon N, Carone M.   +3 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Machine Learning Approach for Investigating Variable Importance in Relationship and Sexual Satisfaction: The Role of Interpersonal Mindfulness and Psychological Safety. [PDF]

J Marital Fam Ther
Dias Martins C, Vergara RC, Khoury B.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Commentary: Modeling mortality risk in patients with severe COVID-19 from Mexico

Frontiers in Medicine, 2023
Elaheh Sanjari, Sepideh Toosizadeh, Hadi Raeisi Shahraki   +2 more
doaj   +1 more source

Variable importance analysis with interpretable machine learning for fair risk prediction. [PDF]

PLOS Digit Health
Ning Y, Li S, Ng YY, Chia MYC, Gan HN, Tiah L, Mao DR, Ng WM, Leong BS, Doctor N, Ong MEH, Liu N.   +11 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of factors influencing hookwire dislodgement in CT-guided hookwire localization: a retrospective study using variable importance analysis with a random forest model. [PDF]

PeerJ
Baek K, Kim JY, Hong JH.
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Prioritizing Variables for Observational Study Design using the Joint Variable Importance Plot. [PDF]

Am Stat
Liao LD, Zhu Y, Ngo AL, Chehab RF, Pimentel SD.   +4 more
europepmc   +1 more source