Results 121 to 130 of about 5,119,730 (291)

A variable neighborhood search for the last-mile delivery problem during major infectious disease outbreak. [PDF]

Optim Lett, 2022
Jiang L, Zang X, Dong J, Liang C, Mladenovic N.   +4 more
europepmc   +1 more source

Variable neighborhood search for graphical model energy minimization

, 2020
International audienceGraphical models factorize a global probability distribution/energy function as the product/ sum of local functions. A major inference task, known as MAP in Markov Random Fields and MPE in Bayesian Networks, is to find a global ...
Boizumault, Patrice, Loudni, Samir, Loukil, Lakhdar, Allouche, David, Ouali, Abdelkader, Lebbah, Yahia, de Givry, Simon   +6 more
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Critical-Path-Based Variable Neighborhood Descent for the Joint Scheduling of FJSP and AGVs

Mathematics
This study addresses the joint scheduling problem of flexible job shop scheduling and automated guided vehicles with the objective of minimizing the makespan.
Han Jia, Yaming Chen, Qian Tian, Dazhi Pan, Yan Yang   +4 more
doaj   +1 more source

A Multi-Neighborhood Multi-Operator Algorithm for the Uncapacitated Exam Proximity Problem [PDF]

Journal of Systemics, Cybernetics and Informatics, 2015
An algorithm featuring multiple local search operators and multiple neighborhood structures is applied to the uncapacitated exam proximity problem. The use of multiplicity is to enable effective interplay between intensification and diversification ...
Tony Wong, Salah Assal
doaj  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Variable Neighborhood Search for Multi-Port Berth Allocation with Vessel Speed Optimization

Journal of Marine Science and Engineering
This paper delves into the multi-port berth allocation problem (MBAP), enriching the traditional berth allocation problem (BAP) with vessel speed optimization (VSO).
Yalong Song, Bin Ji, Samson S. Yu
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Optimization of high-performance concrete structures by variable neighborhood search

, 2013
[EN] This paper describes a methodology in designing high-performance concrete for simply supported beams, using a hybrid optimization strategy based on a variable neighborhood search threshold acceptance algorithm.
Torres Machí, Cristina, Yepes, V., Alcalá-González, Julián, Pellicer, Eugenio   +3 more
core  

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source