Results 121 to 130 of about 5,702,760 (334)

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

open access: yesFEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman   +3 more
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Using Machine Learning Method for Variable Star Classification Using the TESS Sectors 1–57 Data

open access: yesThe Astrophysical Journal
The Transiting Exoplanet Survey Satellite is a wide-field all-sky survey mission designed to detect Earth-sized exoplanets. After over 4 yr of photometric surveys, data from sectors 1–57, including approximately 1,050,000 light curves with a 2 minute ...
Li-Heng Wang   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Hα Variability of AB Aur b with the Hubble Space Telescope: Probing the Nature of a Protoplanet Candidate with Accretion Light Echoes

open access: yesThe Astronomical Journal
Giant planets generate accretion luminosity as they form. Much of this energy is radiated in strong H α line emission, which has motivated direct imaging surveys at optical wavelengths to search for accreting protoplanets.
Brendan P. Bowler   +13 more
doaj   +1 more source

Study of variable extinction of hot stars with circumstellar dust shells [PDF]

open access: yes
Various projects on the topic of hot stars with circumstellar dust are reported. The surface temperature, wind speed, and interstellar reddening were determined for the variable WC7 star HD 193793.

core   +1 more source

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